High-Throughput Screening of Molecular Catalysts Using Automated Liquid Handling, Injection, and Microdevices
| Autor: | Nathalie Pestre, Sylvain Caravieilhes, Thierry Lamouille, Radwan Abdallah, Pierre Grenouillet, Claude de Bellefon |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
business.industry
Chemistry High-throughput screening Asymmetric hydrogenation Analytical chemistry Mixing (process engineering) Substrate (chemistry) General Medicine General Chemistry Allylic alcohol Homogeneous catalysis Catalysis Kinetics Microreactor Process engineering business QD1-999 Isomerization |
| Zdroj: | CHIMIA, Vol 56, Iss 11 (2002) |
| ISSN: | 2673-2424 0009-4293 |
| DOI: | 10.2533/000942902777680018 |
| Popis: | A new concept for the high-throughput screening of multiphase reactions involving molecular catalysts is described. It combines pulse injections of catalysts and substrate and mixing in a microdevice. The novelty of the concept resides in dynamic sequential vs. batchwise operations. Some advantages over traditional batch parallel operations are lower inventory of sample (down to ?g) coupled with accurate control of reaction time, larger range of operating conditions (pressure, temperature), simpler and fewer electromechanical moving parts and easy automation. Results on liquid–liquid (biphasic allylic alcohol isomerization), and gas–liquid (asymmetric hydrogenation) reactions indicates that the number of tests per day can easily reach 50d?1 with inventory of sample (Rh) per test as low as 5 ?g. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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