The secretogranin-II derived peptide secretoneurin modulates electric behavior in the weakly pulse type electric fish, Brachyhypopomus gauderio
| Autor: | Laura Quintana, Paula Pouso, Vance L. Trudeau, Gustavo M. Somoza, Ana Silva, Gabriela C. López |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Vasopressin SECRETONEURIN Otras Ciencias Biológicas Neuropeptide Vasotocin Biology ELECTRIC ORGAN DISCHARGE Ciencias Biológicas chemistry.chemical_compound Endocrinology Internal medicine medicine Animals Electric fish Secretoneurin Neuropeptides VASOTOCIN Cell biology Preoptic area PREOPTIC AREA medicine.anatomical_structure PACEMAKER NUCLEUS chemistry Oxytocin Secretogranin II Animal Science and Zoology Nucleus NEUROPEPTIDE CIENCIAS NATURALES Y EXACTAS Electric Fish medicine.drug |
| Zdroj: | General and Comparative Endocrinology. 222:158-166 |
| ISSN: | 0016-6480 |
| DOI: | 10.1016/j.ygcen.2015.06.015 |
| Popis: | Secretoneurin (SN) in the preoptic area and pituitary of mammals and fish has a conserved close association with the vasopressin and oxytocin systems, members of a peptide family that are key in the modulation of sexual and social behaviors. Here we show the presence of SN-immunoreactive cells and projections in the brain of the electric fish, Brachyhypopomus gauderio. Secretoneurin colocalized with vasotocin (AVT) and isotocin in cells and fibers of the preoptic area. In the rostral pars distalis of the pituitary, many cells were both SN and prolactin-positive. In the hindbrain, at the level of the command nucleus of the electric behavior (pacemaker nucleus; PN), some of SN-positive fibers colocalized with AVT. We also explored the potential neuromodulatory role of SN on electric behavior, specifically on the rate of the electric organ discharge (EOD) that signals arousal, dominance and subordinate status. Each EOD is triggered by the command discharge of the PN, ultimately responsible for the basal EOD rate. SN modulated diurnal basal EOD rate in freely swimming fish in a context-dependent manner; determined by the initial value of EOD rate. In brainstem slices, SN partially mimicked the in vivo behavioral effects acting on PN firing rate. Taken together, our results suggest that SN may regulate electric behavior, and that its effect on EOD rate may be explained by direct action of SN at the PN level through either neuroendocrine and/or endocrine mechanisms. Fil: Pouso, Paula. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay. Universidad de la República; Uruguay Fil: Quintana, Laura. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay Fil: Lopez, Gabriela Carina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Somoza, Gustavo Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina Fil: Silva, Ana C.. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay. Universidad de la República; Uruguay Fil: Trudeau, Vance L.. University of Ottawa; Canadá |
| Databáze: | OpenAIRE |
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