Urinary oxidized, but not enzymatic vitamin E metabolites are inversely associated with measures of glucose homeostasis in middle-aged healthy individuals
| Autor: | Diana van Heemst, Fleur L. Meulmeester, Nadia Ashrafi, Dennis O. Mook-Kanamori, Frits R. Rosendaal, Kevin Mills, Raymond Noordam, Jiao Luo, Renée de Mutsert, Ko Willems van Dijk, Saskia le Cessie, Leon G. Martens |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine Metabolite medicine.medical_treatment Urine Critical Care and Intensive Care Medicine Glucose homeostasis Body Mass Index Lipid peroxidation chemistry.chemical_compound 0302 clinical medicine Homeostasis Vitamin E Prospective Studies Netherlands education.field_of_study Nutrition and Dietetics Middle Aged Healthy Volunteers Postprandial Female Oxidation-Reduction Vitamin E Alpha-tocopherol Glucose homeostasis Insulin resistance medicine.medical_specialty Population 030209 endocrinology & metabolism 03 medical and health sciences Insulin resistance Internal medicine medicine Humans Chromans education Aged 030109 nutrition & dietetics business.industry medicine.disease Cross-Sectional Studies Endocrinology chemistry Linear Models Alpha-tocopherol Lipid Peroxidation Propionates alpha-Tocopherol business |
| Zdroj: | Clinical Nutrition Clinical Nutrition, 40(6), 4192-4200. ELSEVIER Clinical Nutrition, 40(6), 4192-4200. CHURCHILL LIVINGSTONE |
| Popis: | Background & aims: Damage induced by lipid peroxidation has been associated with impaired glucose homeostasis. Vitamin E (alpha-tocopherol, alpha-TOH) competitively reacts with lipid peroxyl radicals to mitigate oxidative damage, and forms oxidized vitamin E metabolites. Accordingly, we aimed to investigate the associations between alpha-TOH metabolites (oxidized and enzymatic) in both circulation and urine and measures of glucose homeostasis in the general middle-aged population. Methods: This cross-sectional study was embedded in the population-based Netherlands Epidemiology of Obesity (NEO) Study. alpha-TOH metabolites in blood (alpha-TOH and alpha-CEHC-SO3) and urine [sulfate (SO3) and glucuronide (GLU) of both alpha-TLHQ (oxidized) and alpha-CEHC (enzymatic)] were quantified by liquid chromatography coupled with tandem mass spectrometry (LC/MSeMS). Measures of glucose homeostasis (HOMA-B, HOMA-IR, Insulinogenic index and Matsuda index) were obtained from fasting and postprandial blood samples. Multivariable linear regression analyses were performed to assess the associations of alpha-TOH metabolites and measures of glucose homeostasis. Results: We included 498 participants (45% men) with mean (SD) age of 55.8 (6.1) years who did not use glucose-lowering medication. While blood alpha-TOH was not associated with measures of glucose homeostasis, urinary oxidized metabolites (alpha-TLHQ-SO3/GLU) were associated with HOMA-IR and Matsuda index. For example, a one-SD higher alpha-TLHQ-SO3 was associated with 0.92 (95% CI: 0.87, 0.97) fold lower HOMA-IR and 1.06 (1.01, 1.11) fold higher Matsuda index, respectively. Similar results were obtained for the urinary alpha-TLHQ to alpha-CEHC ratio as a measure of oxidized-over-enzymatic conversion of alpha-TOH. Conclusion: Higher urinary levels of oxidized alpha-TOH metabolites as well as higher oxidized-to-enzymatic alpha-TOH metabolite ratio, but not circulating alpha-TOH or enzymatic metabolites, were associated with lower insulin resistance. Rather than circulating alpha-TOH, estimates of the conversion of alpha-TOH might be informative in relation to health and disease. (c) 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/ |
| Databáze: | OpenAIRE |
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