N-acetylcysteine is able to reduce the oxidation status and the endothelial activation after a high-glucose content meal in patients with Type 2 diabetes mellitus
Autor: | V. Martina, Fiorella Biasi, S. Dinatale, Loredana Brocato, Cinzia Mascia, Andi Masha |
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Rok vydání: | 2009 |
Předmět: |
Male
medicine.medical_specialty Antioxidant DMT2 Endothelium oxidation Endocrinology Diabetes and Metabolism medicine.medical_treatment Vascular Cell Adhesion Molecule-1 endothelial activation Type 2 diabetes medicine.disease_cause Acetylcysteine Endothelial activation Endocrinology Diabetes mellitus Internal medicine Malondialdehyde Medicine Humans Insulin oxidative stress diabetes N acetylcysteine Aged Aldehydes business.industry Type 2 Diabetes Mellitus Free Radical Scavengers Middle Aged medicine.disease Postprandial Period N-acetylcysteine Oxidative Stress medicine.anatomical_structure Glucose Diabetes Mellitus Type 2 Glycemic Index Case-Control Studies Female Endothelium Vascular business E-Selectin Oxidation-Reduction Oxidative stress medicine.drug |
Zdroj: | Journal of endocrinological investigation. 32(4) |
ISSN: | 1720-8386 |
Popis: | Post-prandial hyperglycemia seems to play a pivotal role in the pathogenesis of the cardiovascular complications of diabetes mellitus, as it leads to an oxidative stress which in turn causes a reduced NO bioavailability. These conditions produce an endothelial activation. Aim of the study: The aim of this study was to assure that the administration of N-acetylcysteine (NAC), thiolic antioxidant, is able to decrease the oxidation status and endothelial activation after a high-glucose content meal. Subjects and methods: Ten patients with Type 2 diabetes mellitus (DMT2) (Group 1) and 10 normal subjects (Group 2) were studied. They assumed a high-glucose content meal without (phase A) or after (phase B) the administration of NAC. Glycemia, insulinemia, intercellular adhesion molecule 1, vascular adhesion molecule 1 (VCAM-1), E-selectin, malonaldehyde (MDA), and 4-hydroxynonenal (HNE) were assessed at −30, 0, +30, +60, +90, +120, and +180 min with respect to the meal consumption. Results: During the phase A in Group 1, only HNE and MDA levels increased after the meal assumption; all parameters remained unchanged in Group 2. During the phase B, in Group 1, HNE, MDA, VCAM-1, and E-selectin levels after the meal were lower than those in phase A, while no change for all variables were observed in Group 2. Conclusions: A high-glucose meal produces an increase in oxidation parameters in patients with DMT2. The administration of NAC reduces the oxidative stress and, by doing so, reduces the endothelial activation. In conclusion, NAC could be efficacious in the slackening of the progression of vascular damage in DMT2. |
Databáze: | OpenAIRE |
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