2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2

Autor:	Frank U. Axe, Johnathan C. Buma, Lars Karlsson, Raymond Rynberg, Michael D. Hack, J. Guy Breitenbucher, Jonathan M. Blevitt, Alice Lee-Dutra, Danielle K. Neff, Anders Brunmark
Rok vydání:	2007
Předmět:	Benzimidazole Stereochemistry Clinical Biochemistry Pharmaceutical Science Protein Serine-Threonine Kinases Biochemistry Chemical synthesis chemistry.chemical_compound Drug Discovery Amines Molecular Biology Protein Kinase Inhibitors Alkyl chemistry.chemical_classification biology Aryl Organic Chemistry Active site Hydrogen Bonding Combinatorial chemistry Checkpoint Kinase 2 chemistry Alcohols biology.protein Molecular Medicine Mitsunobu reaction Amine gas treating Benzimidazoles Linker
Zdroj:	Bioorganicmedicinal chemistry letters. 17(23)
ISSN:	1464-3405
Popis:	A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82bee811cb903470d3cc8f3d7cf9271 https://pubmed.ncbi.nlm.nih.gov/17937984 Zobrazit plný text záznamu Full Text from ScienceDirect