Evaluation of anticonvulsant and neuroprotective effects of camel milk in strychnine-induced seizure model
| Autor: | Rahila Najam, Humera Khatoon, Humera Anser, Talat Mirza, Bushra Sikandar, Humera Ishaq |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
endocrine system Antioxidant lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 medicine.medical_treatment lcsh:Medicine Pharmacology Neuroprotection chemistry.chemical_compound medicine Camel milk Anticonvulsant Hippocampus protection business.industry lcsh:R Strychnine Reference drug Infectious Diseases Mechanism of action chemistry medicine.symptom business Diazepam medicine.drug |
| Zdroj: | Asian Pacific Journal of Tropical Disease, Vol 5, Iss 10, Pp 817-820 (2015) |
| ISSN: | 2222-1808 |
| Popis: | Objective To discover the use of camel milk as an alternate medicine for the treatment and prevention of convulsions using strychnine-induced seizure model. Methods Thirty animals were divided into three equal groups. Group I was on distilled water, Group II was on camel milk for 15 days prior to experiment and Group III was on reference drug diazepam. On the day of experiment, strychnine was administered in all treatment groups after distilled water, camel milk and diazepam treatments respectively. Animals were observed for 30 min for latency of seizure onset, frequency of convulsions and duration of jerks. The mortality rate was also evaluated for each group. Results Camel milk treatment showed significant seizure protection as observed by delayed seizure onset ( P ≤ 0.001), decreased total duration of convulsions ( P ≤ 0.001) and mortality rate ( P ≤ 0.001) when compared with Group I. Conclusions Anticonvulsant activity of camel milk could be due to potentiation of glycinergic and GABAergic activities both. Antioxidant activity can also amplify its antiepileptic activity. Further studies are required to confirm the exact mechanism of action. |
| Databáze: | OpenAIRE |
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