Managing the overlap of asthma and chronic obstructive pulmonary disease
| Autor: | Anne Knight |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Psychological intervention urologic and male genital diseases Article corticosteroids 03 medical and health sciences 0302 clinical medicine medicine COPD obstructive lung disease Pharmacology (medical) inhalers 030212 general & internal medicine Respiratory system Intensive care medicine Asthma business.industry asthma medicine.disease Obstructive lung disease bronchodilators respiratory tract diseases Clinical trial Bronchoconstriction eosinophils medicine.symptom Airway business |
| Zdroj: | Australian Prescriber |
| ISSN: | 1839-3942 |
| DOI: | 10.18773/austprescr.2020.002 |
| Popis: | Approximately 20% of patients with obstructive lung disease have features of both asthma and chronic obstructive pulmonary disease These patients have a higher burden of disease and increased exacerbations compared to those with asthma or chronic obstructive pulmonary disease alone Management should address dominant clinical features in each individual patient, and comorbidities should be considered There are several interventions that are useful in the management of both asthma and chronic obstructive pulmonary disease As inhaled corticosteroids are key to the management of asthma, they are recommended in patients with overlapping chronic obstructive pulmonary disease Keywords: asthma, bronchodilators, COPD, corticosteroids, eosinophils, inhalers, obstructive lung disease Introduction Asthma and chronic obstructive pulmonary disease (COPD) are both common inflammatory diseases of the airways. They are usually distinct disorders but approximately 20% of patients with obstructive lung disease will have features of both conditions.1,2 Asthma–COPD overlap is a term sometimes used to refer to this group of patients, but consensus on a precise definition is lacking.2 Contributing to the controversy around a definition is the heterogeneity of clinical manifestations within this group and the relative importance of each disorder in an individual.3 COPD is characterised by persistent respiratory symptoms and airflow limitation, due to a combination of small airways disease and parenchymal destruction (i.e. emphysema). It is usually caused by exposure to noxious gases and particles, most commonly tobacco smoke.4 Asthma is characterised by variable respiratory symptoms and airway narrowing from bronchoconstriction and airway inflammation. Dual diagnoses of asthma and COPD have often been an exclusion criterion for clinical trials investigating the individual conditions. This has limited the availability of evidence to guide clinical management. A global survey on the diagnosis and management of asthma– COPD overlap highlighted uncertainty among GPs and specialists on the clinical approach to this group of patients.5 |
| Databáze: | OpenAIRE |
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