Antimicrobial Photoinactivation Approach Based on Natural Agents for Control of Bacteria Biofilms in Spacecraft
| Autor: | Lilija Kalėdienė, Pranciškus Vitta, Irina Buchovec, Alisa Gricajeva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
030103 biophysics antibacterial photoinactivation natural photosensitizers spacecraft biofilm decontamination Review Bacterial Physiological Phenomena Catalysis Inorganic Chemistry Bioburden lcsh:Chemistry 03 medical and health sciences Humans Microbiome Physical and Theoretical Chemistry Spacecraft Molecular Biology lcsh:QH301-705.5 Spectroscopy Photosensitizing Agents biology Bacteria Planktonic bacteria business.industry Organic Chemistry fungi Biofilm General Medicine Space Flight biology.organism_classification Antimicrobial Computer Science Applications Anti-Bacterial Agents 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Biofilms Environmental science Biochemical engineering business |
| Zdroj: | International Journal of Molecular Sciences International journal of molecular sciences, Basel : MDPI, 2020, vol. 21, no. 18, art. no. 6932, p. [1-27] International Journal of Molecular Sciences, Vol 21, Iss 6932, p 6932 (2020) |
| ISSN: | 1422-0067 |
| Popis: | A spacecraft is a confined system that is inhabited by a changing microbial consortium, mostly originating from life-supporting devices, equipment collected in pre-flight conditions, and crewmembers. Continuous monitoring of the spacecraft’s bioburden employing culture-based and molecular methods has shown the prevalence of various taxa, with human skin-associated microorganisms making a substantial contribution to the spacecraft microbiome. Microorganisms in spacecraft can prosper not only in planktonic growth mode but can also form more resilient biofilms that pose a higher risk to crewmembers’ health and the material integrity of the spacecraft’s equipment. Moreover, bacterial biofilms in space conditions are characterized by faster formation and acquisition of resistance to chemical and physical effects than under the same conditions on Earth, making most decontamination methods unsafe. There is currently no reported method available to combat biofilm formation in space effectively and safely. However, antibacterial photodynamic inactivation based on natural photosensitizers, which is reviewed in this work, seems to be a promising method. |
| Databáze: | OpenAIRE |
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