Synthesis and anticonvulsant activity of new phenytoin derivatives
| Autor: | Nadia A. Khalil, Yara El-Dash, Bassem H. Naguib, S. Botros |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Phenytoin
medicine.medical_treatment Triazole Motor Activity Pharmacology Rotarod performance test Mice chemistry.chemical_compound Seizures Drug Discovery medicine Animals Motor activity Electroshock Molecular Structure Organic Chemistry Neurotoxicity General Medicine medicine.disease Maximal electroshock Anticonvulsant chemistry Rotarod Performance Test Anticonvulsants medicine.drug |
| Zdroj: | European Journal of Medicinal Chemistry. 60:57-63 |
| ISSN: | 0223-5234 |
| DOI: | 10.1016/j.ejmech.2012.11.025 |
| Popis: | Hybrids between phenytoin and thiosemicarbazide, 1,3,4-oxadiazole, 1,3,4-thiadiazole or 1,2,4-triazole were synthesized and tested for anticonvulsant activity. Preliminary anticonvulsant screening was performed using standard maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens in mice. The neurotoxicity was determined applying the rotarod test. Among these compounds, 4 and 5d showed the highest protection (80%) in the scPTZ test at a dose of 100 mg/kg, whereas the compound 5b displayed promising anticonvulsant effect in the MES model. |
| Databáze: | OpenAIRE |
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