Effect of Alzheimer's disease risk and protective factors on cognitive trajectories in subjective memory complainers: An INSIGHT-preAD study

Autor: Stéphane Epelbaum, M. Kilani, S. Cherif Touil, Bruno Dubois, M. Thiebaut, M.C. Potier, G. Dalla Barba, K. Santos-Andrade, R. Schindler, V. Simon, Stéphane Lehéricy, Catherine Poisson, V. Causse, Olga Uspenskaya, Fanny Mochel, H. Hewa, H. Francisque, I. Masetti, Laurie Boukadida, M. Vlaincu, Patrizia A. Chiesa, A. Mendes, Federica Cacciamani, Michael D. Greicius, Michel J. Grothe, Luisa Sambati, Aurélie Kas, A. Genin, F. Gombert, S. Lista, S. Ratovohery, S. Epelbaum, Marie-Claude Potier, B. Fontaine, J. Ly, P. Glasman, G. Gagliardi, Simone Lista, F. Poirier, Marie-Odile Habert, M.O. Habert, Marion Dubois, Stefan J. Teipel, Katrine Rojkova, Habib Benali, Harald Hampel, M. Lowrey, C. Audrain, M.C. Servera, D. Skovronsky, Francis Nyasse, Remy Genthon, Marcel Levy, Marie Revillon, R. Nait Arab, Geoffroy Gagliardi, A. Michon, Nicola Toschi, A. Dos Santos, Marion Houot, V. La Corte, M. Depaulis, Enrica Cavedo, Anne Bertrand, Olivier Colliot, A. Auffret, O. Makiese, C. Perrin, Hovagim Bakardjian, Bénédicte Batrancourt, Hugo Bertin, Filippo Baldacci, L. Seux, Christiane Metzinger, N. Jungalee, C. Letondor, F. Le Roy, I. Benakki
Přispěvatelé: Teipel, Stefan J, Cavedo, Enrica, Lista, Simone, Habert, Marie-Odile, Potier, Marie-Claude, Grothe, Michel J, Epelbaum, Stephane, Sambati, Luisa, Gagliardi, Geoffroy, Toschi, Nicola, Greicius, Michael D, Dubois, Bruno, Hampel, Harald, Dalla Barba, Gianfranco
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
psychology [Alzheimer Disease]
Epidemiology
epidemiology [Alzheimer Disease]
Hippocampus
Subjective memory
Disease
Preclinical Alzheimer's disease
0302 clinical medicine
Cognition
pathology [Brain]
Longitudinal Studies
Cholinergic basal forebrain
Aged
80 and over
Health Policy
Settore FIS/07
05 social sciences
Brain
metabolism [Memory Disorders]
Organ Size
Amyloid PET
Longitudinal cognitive change
Psychiatry and Mental health
Cohort
Disease Progression
Educational Status
Female
Psychology
metabolism [Alzheimer Disease]
Cognitive psychology
Amyloid
diagnostic imaging [Memory Disorders]
050105 experimental psychology
03 medical and health sciences
Cellular and Molecular Neuroscience
Diagnostic Self Evaluation
Hippocampu
Atrophy
Apolipoproteins E
Developmental Neuroscience
Alzheimer Disease
Cognitive change
medicine
Humans
0501 psychology and cognitive sciences
ddc:610
diagnostic imaging [Brain]
epidemiology [Memory Disorders]
Aged
metabolism [Amyloid]
Memory Disorders
Protective Factors
medicine.disease
Nonlinear Dynamics
metabolism [Brain]
Disease risk
genetics [Apolipoproteins E]
Neurology (clinical)
Geriatrics and Gerontology
diagnostic imaging [Alzheimer Disease]
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Alzheimer's and dementia 14(9), 1126-1136 (2018). doi:10.1016/j.jalz.2018.04.004
DOI: 10.1016/j.jalz.2018.04.004
Popis: Introduction Cognitive change in people at risk of Alzheimer's disease (AD) such as subjective memory complainers is highly variable across individuals. Methods We used latent class growth modeling to identify distinct classes of nonlinear trajectories of cognitive change over 2 years follow-up from 265 subjective memory complainers individuals (age 70 years and older) of the INSIGHT-preAD cohort. We determined the effect of cortical amyloid load, hippocampus and basal forebrain volumes, and education on the cognitive trajectory classes. Results Latent class growth modeling identified distinct nonlinear cognitive trajectories. Education was associated with higher performing trajectories, whereas global amyloid load and basal forebrain atrophy were associated with lower performing trajectories. Discussion Distinct classes of cognitive trajectories were associated with risk and protective factors of AD. These associations support the notion that the identified cognitive trajectories reflect different risk for AD that may be useful for selecting high-risk individuals for intervention trials.
Databáze: OpenAIRE
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