Insulin Combined with Glucose Improves Spatial Learning and Memory in Aluminum Chloride-Induced Dementia in Rats
| Autor: | Chamallamudi Mallikarjuna Rao, Madhavan Nampoothiri, Nampurath Gopalan Kutty, Grandhi Venkata Ramalingayya, Nandakumar Krishnadas |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis medicine.medical_treatment Morris water navigation task Hippocampus Toxicology medicine.disease_cause Pathology and Forensic Medicine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chlorides Memory Internal medicine medicine Aluminum Chloride Animals Insulin Rats Wistar Aluminum Compounds Maze Learning Cognitive deficit business.industry General Medicine medicine.disease Acetylcholinesterase Rats Endocrinology Glucose chemistry 030220 oncology & carcinogenesis Cholinergic Dementia medicine.symptom Alzheimer's disease business 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 36(2) |
| ISSN: | 2162-6537 |
| Popis: | Therapeutic intervention using drugs against Alzheimer disease is curative clinically. At present, there are no reports on the curative role of insulin in chronic models of dementia. We evaluated the curative role of insulin and its combination with glucose in dementia. We also investigated the impact of treatments on blood glucose to correlate with cognitive deficit. Further, we analyzed the interaction of treatments with the cholinergic system and oxidative stress in memory centers (i.e., hippocampus and frontal cortex). The antidementia activity of insulin was assessed against aluminum chloride (AlCl3)-induced dementia in rats. Behavioral parameters (Morris water maze test) along with biochemical parameters (Hippocampus and frontal cortex) such as acetylcholinesterase (AChE), catalase, and glutathione (GSH) levels were assessed to correlate cognitive function with cholinergic transmission and oxidative stress. Rats administered insulin and glucose showed improved cognitive function in the Morris water maze test. The combination corrected the diminished level of antioxidant enzymes such as catalase and GSH in the hippocampus and frontal cortex.Combined administration of insulin and glucose to aluminum-treated rats did not inhibit the aluminum action on the acetylcholinesterase enzyme. No significant changes were observed in blood glucose levels between the treatment groups. |
| Databáze: | OpenAIRE |
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