Changes in body mass index and hemoglobin concentration in breastfeeding women living with HIV with a CD4 count over 350: Results from 4 African countries (The ANRS 12174 trial)
| Autor: | Somé, Eric, Engebretsen, Ingunn Marie S., Nagot, Nicolas, Meda, Nicolas Y, Vallo, Roselyne, Kankasa, Chipepo, Tumwine, James K, Singata, Mandisa, Hofmeyr, Justus G, Van De Perre, Philippe, Tylleskär, Thorkild, Marechal, Valerie, Neveu, Dorine, Foulongne, Vincent, Segondy, Michel, Schaub, Roxanne, Blanche, Stephane, Treluyer, Jean-Marc, Hirt, Deborah, Karamagi, Charles, Musoke, Philippa, Ndeezi, Grace, Mugaba, Proscovia M, Kwagala, Mary, Murungi, Joan, Muweesi, Hawa Nabuuma, Ninsiima, Evelyn, Baryeija, Simon, Ouedraogo, Rasmata, Ye, Diarra, Traore, Hugues A, Nadembega, Christelle, Konate, Justin, Zongo, Arsene, Ouedraogo, Abass, Neboua, Desire, Belemvire, Aissatou, Bambara, Armel, Boncoungou, Justine, Zoungrana, Danielle, Nikodem, Cheryl, Harper, Kim, Jackson, Debra, Sanders, David, Sunday, Amwe, Okegbe-Eze, Collins, Williams, Xoliswa, Mshweshwe, Nolundi, Henge, Vatiswa, Gomba, Fikiswa, Nikodem, Lada, Khondowe, Oswell, Mwiya, Mwiya, Lusaka, Mildreed, Chizyuka, Mary, Phiri, Mary, Imakando, Billies, Musaku, Mwenechanya, Kapasa, Monica, Rutagwera, David, Clement, Ngondwe, Mwaba, Hilton Mwila, Matoba, Japhet, Mwaba, Hilton, Siumita, Chafye, Chola, Katai, Mwamutanda, Patricia |
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| Přispěvatelé: | Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
RNA viruses
Pediatrics Physiology Maternal Health [SDV]Life Sciences [q-bio] Breastfeeding lcsh:Medicine HIV Infections Pathology and Laboratory Medicine Biochemistry Geographical locations Body Mass Index Families Hemoglobins South Africa 0302 clinical medicine Endocrinology Immunodeficiency Viruses Interquartile range Reproductive Physiology Medicine and Health Sciences Uganda 030212 general & internal medicine lcsh:Science Children 2. Zero hunger Multidisciplinary Lopinavir 3. Good health Breast Feeding Medical Microbiology Viral Pathogens Cohort Viruses Female Pathogens Infants medicine.drug Research Article Adult medicine.medical_specialty Anti-HIV Agents 030231 tropical medicine Zambia Breast milk Microbiology 03 medical and health sciences Young Adult Acquired immunodeficiency syndrome (AIDS) Retroviruses Burkina Faso medicine Lactation Humans Hemoglobin Microbial Pathogens Endocrine Physiology business.industry Lentivirus lcsh:R Organisms Biology and Life Sciences HIV Proteins medicine.disease CD4 Lymphocyte Count Age Groups People and Places Africa Women's Health Population Groupings lcsh:Q Neonatology business Breast feeding Body mass index |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2017, 12 (5), pp.e0177259. ⟨10.1371/journal.pone.0177259⟩ PLoS ONE, Vol 12, Iss 5, p e0177259 (2017) |
| ISSN: | 1932-6203 |
| Popis: | International audience; Breastfeeding is recommended for infants born to HIV-infected women in low-income settings. Both breastfeeding and HIV-infection are energy demanding. Our objective was to explore how exclusive and predominant breastfeeding changes body mass index (BMI) among breastfeeding HIV1-positive women participating in the ANRS12174 trial (clinical trial no NCT0064026). METHODS: HIV-positive women (n = 1 267) with CD4 count \textgreater350, intending to breastfeed HIV-negative infants were enrolled from Burkina Faso, South Africa, Uganda and Zambia and counselled on breastfeeding. N = 1 216 were included in the analysis. The trial compared Lamivudine and Lopinavir/Ritonavir as a peri-exposure prophylaxis. We ran a linear mixed-effect model with BMI as the dependent variable and exclusive or predominant breastfeeding duration as the key explanatory variable. RESULTS: Any breastfeeding or exclusive/predominant) breastfeeding was initiated by 99.6% and 98.6% of the mothers respectively in the first week after birth. The median (interquartile range: IQR) duration of the group that did any breastfeeding or the group that did exclusive /predominant breastfeeding were 9.5 (7.5; 10.6) and 5.8 (5.6; 5.9)) months, respectively. The median (IQR) age, BMI, CD4 count, and HIV viral load at baseline (day 7) were 27 (23.3; 31) years, 23.7 (21.3; 27.0) kg/m2, 530 (432.5; 668.5) cells/μl and 0.1 (0.8; 13.7)1000 copies/mL, respectively. No major change in mean BMI was seen in this cohort over a 50-week period during lactation. The mean change between 26 and 50 weeks after birth was 0.7 kg/m2. Baseline mean BMI (measured on day 7 postpartum) and CD4 count were positively associated with maternal BMI change, with a mean increase of 1.0 kg/m2 (0.9; 1.0) per each additional baseline-BMI kilogram and 0.3 kg/m2 (0.2; 0.5) for each additional CD4 cell/μl, respectively. CONCLUSION: Breastfeeding was not negatively correlated with the BMI of HIV-1 infected Sub-Saharan African mothers. However, a higher baseline BMI and a CD4 count \textgreater500 cells/μl were associated with maternal BMI during the exclusive/ predominant breastfeeding period. Considering the benefits of breast milk for the infants and the recurrent results from different studies that breastfeeding is not harmful to the HIV-1-infected mothers, this study also supports the WHO 2016 guidelines on infant feeding that mothers living with HIV should breastfeed where formula is not safe for at least 12 months and up to 24 months, given that the right treatment or prophylaxis for the infection is administered. These findings and conclusions cannot be extrapolated to women who are immune-compromised or have AIDS. |
| Databáze: | OpenAIRE |
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