Endogenous morphine and its metabolites in mammals: History, synthesis, localization and perspectives
| Autor: | Yannick Goumon, Julie Vérièpe, Alexis Laux-Biehlmann, Jinane Mouheiche |
|---|---|
| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Goumon, Yannick |
| Rok vydání: | 2013 |
| Předmět: |
medicine.drug_class
Dopamine Analgesic MESH: Neurons Endogeny Inflammation MESH: Dopamine Pharmacology MESH: Mammals [SCCO]Cognitive science MESH: Opioid Peptides Opioid receptor medicine Animals MESH: Animals Mammals Neurons Morphine Derivatives Morphine Chemistry General Neuroscience [SCCO] Cognitive science History 20th Century MESH: Astrocytes MESH: Morphine Opioid Peptides Astrocytes MESH: Morphine Derivatives TLR4 MESH: History 20th Century μ-opioid receptor medicine.symptom medicine.drug |
| Zdroj: | Neuroscience Neuroscience, 2013, 233, pp.95-117. ⟨10.1016/j.neuroscience.2012.12.013⟩ |
| ISSN: | 0306-4522 1873-7544 |
| DOI: | 10.1016/j.neuroscience.2012.12.013 |
| Popis: | International audience; Morphine derived from Papaver somniferum is commonly used as an analgesic compound for pain relief. It is now accepted that endogenous morphine, structurally identical to vegetal morphine-alkaloid, is synthesized by mammalian cells from dopamine. Morphine binds mu opioid receptor and induces antinociceptive effects. However, the exact role of these compounds is a matter of debate although different links with infection, sepsis, inflammation, as well as major neurological pathologies (Parkinson's disease, schizophrenia) have been proposed. The present review describes endogenous morphine and morphine derivative discovery, synthesis, localization and potential implications in physiological and pathological processes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect