Glutamatergic treatment strategies for age-related memory disorders
| Autor: | Walter E. Müller, S. Stoll, K. Scheuer |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Aging
N-Methylaspartate Hippocampus Glutamic Acid Neurotransmission Receptors N-Methyl-D-Aspartate General Biochemistry Genetics and Molecular Biology Glutamatergic Cognition Acetamides Medicine Animals Humans General Pharmacology Toxicology and Pharmaceutics Cognitive decline Receptor Nootropic Agents Memory Disorders business.industry General Medicine nervous system Cycloserine Glycine NMDA receptor business Neuroscience |
| Zdroj: | Life sciences. 55(25-26) |
| ISSN: | 0024-3205 |
| Popis: | Age-related changes of N-methyl-D-aspartate (NMDA) receptors have been found in cortical areas and in the hippocampus of many species. On the basis of a variety of experimental observations it has been suggested that the decrease of NMDA receptor density might be one of the causative factors of the cognitive decline with aging. Based on these findings several strategies have been developed to improve cognition by compensating the NMDA receptor deficits in aging. The most promising approaches are the indirect activation of glutamatergic neurotransmission by agonists of the glycine site or the restoration of the age-related deficit of receptor density by several nootropics. |
| Databáze: | OpenAIRE |
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