Sleep disorders and melatonin rhythms in elderly people
| Autor: | Peretz Lavie, Arie Shlitner, M Souroujon, Paula Herer, D Nof, Moshe Laudon, Nava Zisapel, Iris Haimov, Orna Tzischinsky |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Sleep Wake Disorders medicine.medical_specialty Urinary system Physiology Melatonin Pineal gland Internal medicine Insomnia Medicine Humans Circadian rhythm General Environmental Science Aged Aged 80 and over Sleep disorder business.industry General Engineering General Medicine medicine.disease Sleep in non-human animals Circadian Rhythm medicine.anatomical_structure Endocrinology General Earth and Planetary Sciences Population study Female medicine.symptom business medicine.drug Research Article |
| Zdroj: | BMJ (Clinical research ed.). 309(6948) |
| ISSN: | 0959-8138 |
| Popis: | Biological aging is often associated with problems with sleep and daytime napping.1 There is considerable evidence linking melatonin, produced by the pineal gland, with the sleep-wake cycle. When administered orally to humans or animals it enhances sleep2 and has a synchronising effect on circadian rhythms. Circulating melatonin concentrations decrease in old age, and its time of secretion is delayed.3 We examined whether sleep disorders in old age were associated with changes in concentration of 6-sulphatoxymelatonin, the major urinary measure of melatonin. The study population comprised four groups: (a) eight independently living patients with insomnia (four men, four women, mean age 73.1 (SD 3.9)); (b) 15 patients with insomnia (five men, 10 women, mean age 82.1 (8.8)) who had lived a minimum of six months in a nursing home; (c) 25 elderly patients without sleep disorders (19 … |
| Databáze: | OpenAIRE |
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