1-Acyl-2-lysophosphatidylcholine: phosphatidylglycerol-2-acyltransacylase in lung microsomes and type II pneumocyte-derived cultures
| Autor: | M.F. Frosolono, G.L. Stanford |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
HEPES
Phosphatidylglycerol Lung Neoplasms Biophysics Adenocarcinoma Biochemistry Cell Line chemistry.chemical_compound Endocrinology Lysophosphatidylcholine chemistry Cell culture Acyltransferase Phosphatidylcholine Dipalmitoylphosphatidylcholine Microsomes Microsome Humans lipids (amino acids peptides and proteins) Lung Acyltransferases Cells Cultured |
| Zdroj: | Biochimica et biophysica acta. 665(2) |
| ISSN: | 0006-3002 |
| Popis: | The formation of [3H]phosphatidylcholine from 1-acyl-2-lysophosphatidylcholine and 1-acyl-2-[9,10-3H]palmitoylphosphatidylglycerol, presumably by 1-acyl-2-lysophosphatidylcholine : phosphatidylglycerol-2-acyltransacylase (phosphatidylglycerol transacylase), was detected in lung microsomes and Set 4 type II pneumocyte-derived cultured cells but not in A549 adenocarcinoma-derived type II cell analogs. There was greater phosphatidylglycerol transacylase activity in Set 4 cells at confluence than at the mid-log stage. Since the phosphatidylglycerol transacylase activity was always markedly less than that observed for 1-acyl-2-lysophosphatidylcholine : acyl-CoA acyltransferase, the former does not appear to represent a major pathway for synthesis of pulmonary dipalmitoylphosphatidylcholine. |
| Databáze: | OpenAIRE |
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