Sirtuin 1 suppresses nuclear factor κB induced transactivation and pro-inflammatory cytokine expression in cat fibroblast cells
| Autor: | Hiroshi Takemitsu, Ichiro Yamamoto, Shingo Ishikawa, Nobuko Mori, Makoto Habara, Toshiro Arai |
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| Rok vydání: | 2015 |
| Předmět: |
Transcription
Genetic Inflammation Biochemistry fibroblast NF-κB Transactivation chemistry.chemical_compound Sirtuin 1 medicine Animals RNA Messenger feline Fibroblast Cells Cultured General Veterinary biology Fibroblast growth factor receptor 2 NF-kappa B Fibroblasts Note NFKB1 Molecular biology Up-Regulation Cell biology sirtuin medicine.anatomical_structure Gene Expression Regulation chemistry Sirtuin Cats biology.protein Cytokines medicine.symptom |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| Popis: | Nuclear factor κB (NF-κB) is a key factor in the development of chronic inflammation and is deeply involved in age-related and metabolic diseases development. These diseases have become a serious problem in cats. Sirtuin 1 (SIRT1) is associated with aging and metabolism through maintaining inflammation via NF-κB. In addition, fibroblasts are considered an important factor in the development of chronic inflammation. Therefore, we aimed to examine the effect of cat SIRT1 (cSIRT1) on NF-κB in cat fibroblast cells. The up-regulation of NF-κB transcriptional activity and pro-inflammatory cytokine mRNA expression by p65 subunit of NF-κB and lipopolysaccharide was suppressed by cSIRT1 in cat fibroblast cells. Our findings show that cSIRT1 is involved in the suppression of inflammation in cat fibroblast cells. |
| Databáze: | OpenAIRE |
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