Endurance Performance in Humans: The Effect of a Dopamine Precursor or a Specific Serotonin (5-HT2A/2C) Antagonist
| Autor: | J. Roeykens, L. Magnus, Romain Meeusen, K. De Meirleir, H. Keizer |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Physical Therapy Sports Therapy and Rehabilitation Physical exercise Ritanserin Hematocrit Statistics Nonparametric Levodopa Double-Blind Method Dopamine Internal medicine Heart rate medicine Humans Orthopedics and Sports Medicine Analysis of Variance Cross-Over Studies medicine.diagnostic_test Chemistry Antagonist Carbidopa Drug Combinations Endocrinology Dopamine Agonists Exercise Test Physical Endurance Catecholamine Serotonin Antagonists Serotonin Energy Metabolism Blood Chemical Analysis medicine.drug |
| Zdroj: | International Journal of Sports Medicine. 18:571-577 |
| ISSN: | 1439-3964 0172-4622 |
| Popis: | In this study we examined the effect of a dopamine (DA) precursor (L-DOPA) or a serotonin (5-HT) antagonist (Ritanserin) on time to exhaustion. The study had a double-blind, randomised, placebo controlled and cross-over design. Seven moderately trained men performed three tests to exhaustion at 65 % Watt max . Each test was separated by two weeks to allow washout of the drugs (dose: 4 mg/kg Sinemet ® , and 0.3 mg/kg Ritanserin). Blood lactate, hematocrit, glucose, ammonia, free fatty acids (FFA), growth hormone (GH) and catecholamines were determined before and after exercise. Time to exhaustion did not differ between the three trials. Most of the parameters measured in this study responded as predicted during cycling to exhaustion in man. DA agonism significantly increased heart rate, lactate, and plasma DA values at rest, while other parameters such as FFA, lactate, plasma noradrenaline (NA) and adrenaline (A), and plasma GH showed the highest absolute levels at exhaustion. Ritanserin did not influence basal glucose and heart rate at rest, but this group showed a much lower increase in plasma catecholamine levels. We conclude that under the present conditions, neither a metabolic precursor of DA nor a specific centrally acting 5-HT 2A/2C antagonist, when given in two single doses 24 h and immediately before the experiments, influences the time to exhaustion on a bicycle trial at 65 % Watt max . |
| Databáze: | OpenAIRE |
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