Relationship between Maternal Serum C-Reactive Protein, Funisitis and Early-Onset Neonatal Sepsis
| Autor: | Kyung Joon Oh, Kyo Hoon Park, Sung Youn Lee, Eun Ha Jeong, Kyoung Un Park, Aeli Ryu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Fetal Membranes Premature Rupture Funisitis Gestational Age Infant Premature Diseases Preterm Premature Rupture of Membrane Chorioamnionitis Cohort Studies Predictive Value of Tests Pregnancy Sepsis medicine Early-Onset Neonatal Sepsis Humans Age of Onset Retrospective Studies Neonatal sepsis business.industry Obstetrics Preterm Labor Infant Newborn Gestational age Obstetrics & Gynecology General Medicine medicine.disease C-Reactive Protein ROC Curve Premature birth Predictive value of tests Area Under Curve Premature Birth Original Article Female business Premature rupture of membranes Biomarkers Infant Premature |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | The aim of this study was to determine whether maternal serum C-reactive protein (CRP) is of value in predicting funisitis and early-onset neonatal sepsis (EONS) in women with preterm labor or preterm premature rupture of membranes (PROM). This retrospective cohort study included 306 consecutive women with preterm labor or preterm PROM who delivered preterm singleton neonates (23-35 weeks gestation) within 72 hr of CRP measurement. The CRP level was measured with a highly sensitive immunoassay. The sensitivity, specificity, positive predictive value, and negative predictive value of an elevated serum CRP level (≥ 8 mg/L) were 74.1%, 67.5%, 32.8%, and 92.4% for funisitis, and 67.7%, 63.3%, 17.2%, and 94.6% for EONS, respectively. Logistic regression analysis demonstrated that elevated levels of serum CRP were significantly associated with funisitis and EONS, even after adjusting gestational age. The maternal serum CRP level obtained up to 72 hr before delivery is an independent predictor of funisitis and EONS in women with preterm labor or preterm PROM. A low serum CRP level (< 8 mg/L) has good negative predictive value in excluding funisitis and EONS, and may therefore be used as a non-invasive adjunct to clinical judgment to identify low-risk patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|