Genomics and structural insight into the masking of gentamicin-resistance in clinical Burkholderia pseudomallei strain VB29710 from India

Autor:	Yamuna Devi Bakthavatchalam, Soumya Basu, Abirami Shankar, Sudha Ramaiah, Anand Anbarasu, Balaji Veeraraghavan
Rok vydání:	2023
Předmět:	Microbiology (medical) Infectious Diseases General Medicine
Zdroj:	Diagnostic Microbiology and Infectious Disease. 105:115878
ISSN:	0732-8893
Popis:	The present study reported a rare gentamicin-susceptible β-lactamase (PenA, OXA-57) expressing clinical Burkholderia pseudomallei isolate VB29710 from India. Whole-genome sequencing and structural analyses revealed the insertion of R962 and L963 into AmrB, the transmembrane-protein of the AmrAB-OprA efflux-pump that affected aminoglycoside-efflux through local alterations in backbone conformation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f816bd4225a21246aa12d40f9a845e89 https://doi.org/10.1016/j.diagmicrobio.2022.115878 Zobrazit plný text záznamu Full Text from ScienceDirect