Cytokines, Immunoglobulins, and Bacterial Pathogens in Middle Ear Effusions
| Autor: | William J. Doyle, Warren F. Diven, Theresa L. Whiteside, Philip Fireman, Antonio Riera March, Robert F. Yellon |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adolescent
medicine.medical_treatment Immunoglobulins Enzyme-Linked Immunosorbent Assay Inflammation Interferon-gamma Recurrence Interferon medicine Humans Tympanostomy tube Child Bacteria Interleukin-6 Otitis Media with Effusion Tumor Necrosis Factor-alpha business.industry Infant General Medicine Middle Ear Ventilation Cytokine Otitis Otorhinolaryngology Effusion Private practice Child Preschool Chronic Disease Immunology Cytokines Surgery Tumor necrosis factor alpha medicine.symptom business Interleukin-1 medicine.drug |
| Zdroj: | Archives of Otolaryngology - Head and Neck Surgery. 121:865-869 |
| ISSN: | 0886-4470 |
| DOI: | 10.1001/archotol.1995.01890080033006 |
| Popis: | To elucidate the role of cytokines, immunoglobulins, and bacterial pathogens in the middle ear effusions (MEEs) of children with otitis media (OM).Paired MEEs and serum samples collected from consecutive patients were assayed for immunoglobulins. Middle ear effusions were cultured for bacterial pathogens and assayed for interleukin-1 beta, interleukin-6, tumor necrosis factor alpha, and interferon gamma. The medical charts of the patients were retrospectively reviewed to define the history of OM.Seventy-five patients with a history of recurrent acute OM, persistent OM with effusion, or both. Exclusion criteria included the presence of a major coexisting condition, or an unclear or atypical history of OM.A private practice at a tertiary care children's hospital.At the time of tympanostomy tube placement, with the patient under general anesthesia, one MEE and a serum sample were collected.Interleukin-1 beta was detected in 58% (44/75) MEEs; interleukin-6, 83% (60/72); tumor necrosis factor alpha, 37% (28/75) [corrected]; and interferon gamma, 61% (45/74). Concentrations of interleukin-1 beta, interleukin-6 and tumor necrosis factor alpha in MEEs were highly correlated with each other (P.01 for each association) suggesting increased local production and the expected effects of cytokines stimulating their own production during OM. High concentrations of tumor necrosis factor alpha in MEEs were also associated with a history of multiple placements of tympanostomy tubes (r = .63).These data suggest a regulatory role for cytokines in inflammation during OM, and suggest that high concentrations of tumor necrosis factor alpha in MEEs may be a marker for OM chronicity. |
| Databáze: | OpenAIRE |
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