Effect of electrical brain stimulation on erythrocyte membrane lipids
Autor: | Fritz Parl, George Kiu, Loring K. Bjornson, William H. Gutstein |
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Rok vydání: | 1977 |
Předmět: |
Male
medicine.medical_specialty Erythrocytes Time Factors Lateral hypothalamus Central nervous system Phospholipid Hypothalamus Stimulation Biology General Biochemistry Genetics and Molecular Biology Cell membrane chemistry.chemical_compound Membrane Lipids Internal medicine medicine Animals General Pharmacology Toxicology and Pharmaceutics Phospholipids Cholesterol Erythrocyte Membrane General Medicine Electric Stimulation Rats Membrane Endocrinology medicine.anatomical_structure chemistry Electrical brain stimulation |
Zdroj: | Life sciences. 20(12) |
ISSN: | 0024-3205 |
Popis: | Biliary obstruction was induced in rats by intermittent stimulation of the lateral hypothalamus for periods of 2 and 6 hours. Cholesterol and phospholipid concentrations of circulating red blood cells were found to be decreased, whereas in the plasma these lipids were elevated. The mechanism of membrane lipid depletion associated with early biliary obstruction is currently unknown. It is possible, however, that cells other than erythrocytes undergo similar changes. In previous experiments plasma membrane degeneration of endothelial cells was observed in rats subjected to hypothalamic stimulation for 6 hours. Thus, central nervous system stimulation may have a deleterious effect on cell membrane structure and function and be mediated through biliary obstruction. |
Databáze: | OpenAIRE |
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