Effect of electrical brain stimulation on erythrocyte membrane lipids

Autor: Fritz Parl, George Kiu, Loring K. Bjornson, William H. Gutstein
Rok vydání: 1977
Předmět:
Zdroj: Life sciences. 20(12)
ISSN: 0024-3205
Popis: Biliary obstruction was induced in rats by intermittent stimulation of the lateral hypothalamus for periods of 2 and 6 hours. Cholesterol and phospholipid concentrations of circulating red blood cells were found to be decreased, whereas in the plasma these lipids were elevated. The mechanism of membrane lipid depletion associated with early biliary obstruction is currently unknown. It is possible, however, that cells other than erythrocytes undergo similar changes. In previous experiments plasma membrane degeneration of endothelial cells was observed in rats subjected to hypothalamic stimulation for 6 hours. Thus, central nervous system stimulation may have a deleterious effect on cell membrane structure and function and be mediated through biliary obstruction.
Databáze: OpenAIRE