Composition and bioactivity of the leaf essential oil of Heteropyxis dehniae from Zimbabwe
| Autor: | Samson Sibanda, Jennifer M. Schmidt, William N. Setzer, Ephraim T. Gwebu, Angela I. Rea, Joseph A. Noletto, Grace Chigwada, Melvin Poole |
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| Rok vydání: | 2004 |
| Předmět: |
Zimbabwe
Staphylococcus aureus Myrtaceae Bacillus cereus Microbial Sensitivity Tests Heteropyxis Gas Chromatography-Mass Spectrometry Microbiology law.invention chemistry.chemical_compound Anti-Infective Agents Linalool law Cell Line Tumor Candida albicans Drug Discovery Escherichia coli Humans Plant Oils Food science Medicine African Traditional Essential oil Pharmacology biology Aspergillus niger Antimicrobial biology.organism_classification Plant Leaves chemistry Pseudomonas aeruginosa Phytotherapy Pseudomonadaceae |
| Zdroj: | Journal of Ethnopharmacology. 92:107-111 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2004.02.010 |
| Popis: | The leaf oil of Heteropyxis dehniae Suess. (Heteropyxidaceae) was obtained by hydrodistillation and analyzed by GC/MS. The most abundant essential oil components are linalool (58.3%), 4-terpineol (9.8%), α-terpineol (3.6%), and caryophyllene oxide (3.1%). The antimicrobial activity against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Aspergillus niger, and the in vitro cytotoxicity of the oil on PC-3, MDA-MB-231, Hs 578T, MCF7, SK-MEL-28, and 5637 human tumor cells were also examined. Caryophyllene oxide shows notable cytotoxic activity with LC50 values of 147–351 μM. |
| Databáze: | OpenAIRE |
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