The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.: The Mineralocorticoid Receptor
| Autor: | Mathilde Munier, Say Viengchareun, Marc Lombès, Damien Le Menuet, Laetitia Martinerie, Laurent Pascual-Le Tallec |
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| Přispěvatelé: | Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR93-Université Paris-Sud - Paris 11 (UP11), Service d'Endocrinologie et Maladies de la reproduction, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, INSERM and Université Paris-Sud 11 for funding. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Genetically modified mouse
Transcriptional Activation MESH: Cell Nucleus medicine.drug_class [SDV]Life Sciences [q-bio] MESH: Brain Diseases MESH: Metabolic Diseases Review Biology medicine.disease_cause Neuroprotection 03 medical and health sciences 0302 clinical medicine Mineralocorticoid receptor Metabolic Diseases MESH: Receptors Mineralocorticoid medicine Transcriptional regulation Animals Humans MESH: Animals Receptor ComputingMilieux_MISCELLANEOUS 030304 developmental biology Cell Nucleus 0303 health sciences Brain Diseases MESH: Humans MESH: Cardiovascular Diseases General Medicine [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism 3. Good health Receptors Mineralocorticoid Biochemistry Mineralocorticoid Cardiovascular Diseases MESH: Transcriptional Activation Signal transduction Carcinogenesis Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nuclear Receptor Signaling Nuclear Receptor Signaling, Nuclear Receptor Signaling Atlas, 2018, 5 (1), pp.nrs.05012. ⟨10.1621/nrs.05012⟩ Nuclear Receptor Signaling, Nuclear Receptor Signaling Atlas, 2007, 5, pp.e012. ⟨10.1621/nrs.05012⟩ Scopus-Elsevier |
| ISSN: | 1550-7629 |
| DOI: | 10.1621/nrs.05012⟩ |
| Popis: | International audience; The last decade has witnessed tremendous progress in the understanding of the mineralocorticoid receptor (MR), its molecular mechanism of action, and its implications for physiology and pathophysiology. After the initial cloning of MR, and identification of its gene structure and promoters, it now appears as a major actor in protein-protein interaction networks. The role of transcriptional coregulators and the determinants of mineralocorticoid selectivity have been elucidated. Targeted oncogenesis and transgenic mouse models have identified unexpected sites of MR expression and novel roles for MR in non-epithelial tissues. These experimental approaches have contributed to the generation of new cell lines for the characterization of aldosterone signaling pathways, and have also facilitated a better understanding of MR physiology in the heart, vasculature, brain and adipose tissues. This review describes the structure, molecular mechanism of action and transcriptional regulation mediated by MR, emphasizing the most recent developments at the cellular and molecular level. Finally, through insights obtained from mouse models and human disease, its role in physiology and pathophysiology will be reviewed. Future investigations of MR biology should lead to new therapeutic strategies, modulating cell-specific actions in the management of cardiovascular disease, neuroprotection, mineralocorticoid resistance, and metabolic disorders. |
| Databáze: | OpenAIRE |
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