Fast feedback regulation of acth by cortisol
| Autor: | K. Ranga Rama Krishnan, Bernard J. Carroll, Charles B. Nemeroff, Shun Wei Li, James C. Ritchie, Ananth N. Manepalli, Sanjeev Venkataraman, William B. Saunders |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Pharmacology endocrine system medicine.medical_specialty Cortisol awakening response Hydrocortisone Area under the curve HYDROCORTISONE HEMISUCCINATE Feedback regulation Feedback Basal (phylogenetics) Endocrinology Adrenocorticotropic Hormone Internal medicine medicine Humans Psychology hormones hormone substitutes and hormone antagonists Biological Psychiatry medicine.drug |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 15:523-529 |
| ISSN: | 0278-5846 |
| Popis: | 1. Fast feedback regulation of ACTH by cortisol has not been well studied in humans. The authors studied the existence and characteristics of fast feedback regulation in normal humans. 2. Hydrocortisone hemisuccinate was infused at two different rates: 6 mg/hour and 12 mg/hour for two hours. 3. The studies did not demonstrate the existence of fast feedback regulation of basal ACTH concentration by cortisol in man. Further, the response was variable and the rate sensitive character was difficult to demonstrate. |
| Databáze: | OpenAIRE |
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