Late-stage diversification strategy for synthesizing ynamides through copper-catalyzed diynylation and azide–alkyne cycloaddition

Autor:	Ryohei Kawakami, Suguru Usui, Norihiro Tada, Akichika Itoh
Rok vydání:	2023
Předmět:	Materials Chemistry Metals and Alloys Ceramics and Composites General Chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials
Zdroj:	Chemical Communications. 59:450-453
ISSN:	1364-548X 1359-7345
Popis:	A late-stage diversification strategy for synthesizing ynamides has been developed. This strategy was enabled by the copper-catalyzed direct electrophilic diynylation of sulfonamides with a novel triisopropylsilyl diynyl benziodoxolone, deprotection, and the late-stage chemoselective copper-catalyzed azide-alkyne cycloaddition sequence, which yields various complex molecule-derived ynamides with pyrene, amino acid, nucleoside, and
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80fa4dca10f4425bfae020836039f18 https://doi.org/10.1039/d2cc05575a Zobrazit plný text záznamu