The neuroprotective role of Wnt signaling in the retina
| Autor: | Andreas Ohlmann, Stefan Kassumeh, Siegfried G. Priglinger, Matthias Nobl, Gregor R Weber |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
retina
apoptosis β-catenin leukemia inhibitory factor müller cells neurodegeneration neuroprotection norrin photoreceptors retinal ganglion cells wnt Central nervous system Review Biology Norrin Neuroprotection lcsh:RC346-429 Wnt Developmental Neuroscience medicine lcsh:Neurology. Diseases of the nervous system Müller cells Retina Neurodegeneration Wnt signaling pathway medicine.disease Cell biology medicine.anatomical_structure Catenin Signal transduction Leukemia inhibitory factor |
| Zdroj: | Neural Regeneration Research Neural Regeneration Research, Vol 16, Iss 8, Pp 1524-1528 (2021) |
| ISSN: | 1876-7958 1673-5374 |
| Popis: | The canonical Wnt/β-catenin signaling pathway has been shown to play a major role during embryonic development and maturation of the central nervous system including the retina. It has a significant impact on retinal vessel formation and maturation, as well as on the establishment of synaptic structures and neuronal function in the central nervous system. Mutations in components of the Wnt/β-catenin signaling cascade may lead to severe retinal diseases, while dysregulation of Wnt signaling can contribute to disease progression. Apart from the angiogenic role of Wnt/β-catenin signaling, research in the last decades leads to the theory of a protective effect of Wnt/β-catenin signaling on damaged neurons. In this review, we focus on the neuroprotective properties of the Wnt/β-catenin pathway as well as its downstream signaling in the retina. |
| Databáze: | OpenAIRE |
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