Regulatory T cells control strain specific resistance to Experimental Autoimmune Prostatitis
| Autor: | Ruben Dario Motrich, Maria Laura Breser, Andreia C. Lino, Gloria Janet Godoy, Virginia Elena Rivero, Jocelyne Demengeot |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male PROSTATITIS CIENCIAS MÉDICAS Y DE LA SALUD Receptors CXCR3 AUTOIMMUNITY Inmunología Prostatitis Context (language use) Nod Biology CXCR3 medicine.disease_cause T-Lymphocytes Regulatory Article Autoimmunity Autoimmune Diseases TREG 03 medical and health sciences Interferon-gamma 0302 clinical medicine Downregulation and upregulation Mice Inbred NOD medicine Animals Interferon gamma Immunological disorders Mice Knockout Mice Inbred BALB C Multidisciplinary Effector purl.org/becyt/ford/3.1 [https] medicine.disease TH1 Medicina Básica Disease Models Animal 030104 developmental biology Immunology purl.org/becyt/ford/3 [https] 030215 immunology medicine.drug |
| Zdroj: | Scientific Reports CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep33097 |
| Popis: | Susceptibility to autoimmune diseases results from the encounter of a complex and long evolved genetic context with a no less complex and changing environment. Major actors in maintaining health are regulatory T cells (Treg) that primarily dampen a large subset of autoreactive lymphocytes escaping thymic negative selection. Here, we directly asked whether Treg participate in defining susceptibility and resistance to Experimental Autoimmune Prostatitis (EAP). We analyzed three common laboratory strains of mice presenting with different susceptibility to autoimmune prostatitis upon immunization with prostate proteins. The NOD, the C57BL/6 and the BALB/c mice that can be classified along a disease score ranging from severe, mild and to undetectable, respectively. Upon mild and transient depletion of Treg at the induction phase of EAP, each model showed an increment along this score, most remarkably with the BALB/c mice switching from a resistant to a susceptible phenotype. We further show that disease associates with the upregulation of CXCR3 expression on effector T cells, a process requiring IFNγ. Together with recent advances on environmental factors affecting Treg, these findings provide a likely cellular and molecular explanation to the recent rise in autoimmune diseases incidence. Fil: Breser, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Transferencia de Villa María. Universidad Nacional de Villa María. Centro de Investigaciones y Transferencia de Villa María; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Lino, Andreia C.. Instituto Gulbenkian de Ciencia; Portugal Fil: Motrich, Ruben Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Godoy, Gloria Janet. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: Demengeot, Jocelyne. Instituto Gulbenkian de Ciencia; Portugal Fil: Rivero, Virginia Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina |
| Databáze: | OpenAIRE |
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