Vitamins B-12 and C Supplementation Improves Arterial Reactivity and Structure in Passive Smokers: Implication in Prevention of Smoking-Related Atherosclerosis
| Autor: | X. H. Feng, T. W. C. Yip, Alex Pui-Wai Lee, H. C. Leong, K. V. Koon, Kam S. Woo, Ping Chook, Timothy Kwok |
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| Rok vydání: | 2021 |
| Předmět: |
Vitamin
Male medicine.medical_specialty Passive smoking 030309 nutrition & dietetics Medicine (miscellaneous) Ascorbic Acid Placebo medicine.disease_cause Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Internal medicine medicine.artery Diabetes mellitus medicine Humans 030212 general & internal medicine Vitamin B12 Brachial artery 0303 health sciences Nutrition and Dietetics Smokers Vitamin C business.industry Smoking Middle Aged medicine.disease Atherosclerosis Vitamin B 12 Carotid Arteries chemistry Dietary Supplements Female Geriatrics and Gerontology business Body mass index |
| Zdroj: | The journal of nutrition, healthaging. 25(2) |
| ISSN: | 1760-4788 |
| Popis: | Atherosclerosis is an important medical problem of modern society. High environmental tobacco smoke in casino is associated with an accelerated atherogenic process. We have previously shown vitamin B12 and C supplementation improves vascular reactivity and may be beneficial in vascular protection. To evaluate the impact of vitamin supplementation on atherosclerosis (brachial artery reactivity FMD and carotid intima-media thickness IMT) in subjects exposed to high environmental tobacco smoke. Double-blind 2×2 factorial design fashion. Computer randomization in 4 treatment groups: placebo (n=24), vitamin B12 (n=21), vitamin C (n=23) and vitamin B12+C (n=23) groups. 91 passive-smoking casino employees (19.2% male, mean age 45.0±8.2 years). Subjects were randomized to receive vitamin B12 (500µg daily), vitamin C (200mg daily), vitamin B12+C or image-matched placebo capsules for 1 year. Measurement: Brachial FMD and carotid IMT (surrogate atherosclerotic markers) were measured by ultrasound at baseline and on completion at 12 months. 91 passive smoking casino employees (19.2% male, mean age 45.0±8.2 years) were randomized to receive vitamin B12 (500µg daily), vitamin C (200mg daily), vitamin B12+C or image-matched placebo capsules in double-blind 2 × 2 factorial design fashion for 1 year. Brachial FMD and carotid IMT (surrogate atherosclerotic markers) were measured by ultrasound at baseline and 12 months. Of the 78 (85.7%) passive-smoking employees completed the study, 11.5% had hypertension, 5.1% diabetes mellitus and 15.4% hypercholesterolemia. There were no significant changes in their blood pressures, lipid profiles, glucose and body mass index after supplementation for 1 year, but mild decrease in DBP (p |
| Databáze: | OpenAIRE |
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