CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance
| Autor: | Alessandra Valerio, Rocco Latorre, Beat Lutz, Krisztina Monory, Annamaria Grandis, Daniela Cota, Marlène Maitre, Thierry Leste-Lassere, Cristina Cervino, Raj Kamal Srivastava, Laura E. Clemens, Luigi Bellocchio, Cristina Nanni, Giovanni Marsicano, Giacomo Mancini, Marco Bucci, Luzie J. Braulke, Gerhard Heldmaier, Enzo Nisoli, Laura Tedesco, Roberto De Giorgio, Susanne Klaus, Renato Pasquali, Uberto Pagotto, Carmelo Quarta, Stefan Reuss, Roberta Mazza, Masahiko Watanabe, Csaba Fekete, Flaminia Fanelli |
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| Přispěvatelé: | Quarta C., Bellocchio L., Mancini G., Mazza R., Cervino C., Braulke L.J., Fekete C., Latorre R., Nanni C., Bucci M., Clemens L.E., Heldmaier G., Watanabe M., Leste-Lassere T., Maitre M., Tedesco L., Fanelli F., Reuss S., Klaus S., Srivastava R.K., Monory K., Valerio A., Grandis A., De Giorgio R., Pasquali R., Nisoli E., Cota D., Lutz B., Marsicano G., Pagotto U. |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Sympathetic Nervous System
Physiology medicine.medical_treatment HUMDISEASE Fluorescent Antibody Technique Body Temperature Mice 0302 clinical medicine Receptor Cannabinoid CB1 Cannabinoid receptor type 1 Receptor In Situ Hybridization Mice Knockout 0303 health sciences Reverse Transcriptase Polymerase Chain Reaction CB(1) Thermogenesis Endocannabinoid system OBESITY CB1 knock out lipids (amino acids peptides and proteins) CANNABINOID RECEPTOR ENDOCANNABINOID SYSTEM METABOLIC DISORDERS Signal Transduction medicine.medical_specialty forebrain Immunoblotting Citrate (si)-Synthase In situ hybridization Hyperphagia Biology DNA Mitochondrial Models Biological MOLNEURO NO 03 medical and health sciences Prosencephalon Lipid oxidation Internal medicine medicine Animals Molecular Biology 030304 developmental biology Analysis of Variance X-Ray Microtomography Cell Biology endocannabinoid energy balance Endocrinology nervous system sympathetic neurons Forebrain Cannabinoid Energy Metabolism Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell Metabolism |
| Popis: | The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB(1)) has been shown to reduce body weight and to alleviate obesity-related metabolic disorders. An unsolved question is at which anatomical level CB(1) modulates energy balance and the mechanisms involved in its action. Here, we demonstrate that CB(1) receptors expressed in forebrain and sympathetic neurons play a key role in the pathophysiological development of diet-induced obesity. Conditional mutant mice lacking CB(1) expression in neurons known to control energy balance, but not in nonneuronal peripheral organs, displayed a lean phenotype and resistance to diet-induced obesity. This phenotype results from an increase in lipid oxidation and thermogenesis as a consequence of an enhanced sympathetic tone and a decrease in energy absorption. In conclusion, CB(1) signaling in the forebrain and sympathetic neurons is a key determinant of the ECS control of energy balance. |
| Databáze: | OpenAIRE |
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