Predictors of long-term symptom burden and quality of life in patients hospitalised with chest pain: a prospective observational study

Autor: Nasir Saeed, Tone Merete Norekvål, Ole-Thomas Steiro, Hilde Lunde Tjora, Jørund Langørgen, Rune Oskar Bjørneklett, Øyvind Skadberg, Vernon Vijay Singha Bonarjee, Øistein Rønneberg Mjelva, Torbjørn Omland, Kjell Vikenes, Kristin Moberg Aakre
Rok vydání: 2022
Předmět:
Zdroj: e062302
BMJ Open
ISSN: 2044-6055
Popis: ObjectiveTo describe the magnitude and predictors of symptom burden (SB) and quality of life (QoL) 3 months after hospital admission for acute chest pain.DesignProspective observational study.SettingSingle centre, outpatient follow-up.Participants1506 patients.OutcomesScores reported for general health (RAND-12), angina-related health (Seattle Angina Questionnaire 7 (SAQ-7)) and dyspnoea (Rose Dyspnea Scale) 3 months after hospital admission for chest pain.MethodsA total of 1506 patients received questionnaires assessing general health (RAND-12), angina-related health (SAQ-7) and dyspnoea (Rose Dyspnea Scale) 3 months after discharge. Univariable and multivariable regression models identified predictors of SB and QoL scores. A mediator analysis identified factors mediating the effect of an unstable angina pectoris (UAP) diagnosis.Results774 (52%) responded. Discharge diagnoses were non-ST elevation myocardial infarction (NSTEMI) (14.2%), UAP (17.1%), non-coronary cardiac disease (6.6%), non-cardiac disease (6.3%) and non-cardiac chest pain (NCCP) (55.6%). NSTEMI had the most favourable, and UAP patients the least favourable SAQ-7 scores (median SAQ7-summary; 88 vs 75, p±10%) of an UAP diagnosis for all SAQ-7 and RAND-12 outcomes.ConclusionsPatients with NSTEMI reported the most favourable outcome 3 months after hospitalisation for chest pain. Patients with other diseases, in particular UAP patients, reported lower scores. Revascularised NSTEMI and UAP patients reported higher QoL scores compared with patients receiving conservative treatment. Revascularisation mediated all outcomes in UAP patients.Trial registration numberNCT02620202.
Databáze: OpenAIRE
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