Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea
| Autor: | Olivier P. Thomas, Nipun Mahajan, Paul V. Murphy, Enda O' Connell, Kevin Calabro, Rekha Chadda, Hiren Solanki |
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| Přispěvatelé: | National University of Ireland [Galway] (NUI Galway), NCBES, Géoazur (GEOAZUR 7329), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]) |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Chemistry Stereochemistry Organic Chemistry Phenylurea Derivatives [SDU.STU]Sciences of the Universe [physics]/Earth Sciences Lichen Resorcinol Isolation (microbiology) Biochemistry Antioxidants 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Phenylurea Drug Discovery Urea Moiety Lichina pygmaea |
| Zdroj: | Tetrahedron Letters Tetrahedron Letters, Elsevier, 2017, 58 (12), pp.1237-1239. ⟨10.1016/j.tetlet.2017.02.037⟩ Tetrahedron Letters, 2017, 58 (12), pp.1237-1239. ⟨10.1016/j.tetlet.2017.02.037⟩ |
| ISSN: | 0040-4039 1873-3581 |
| DOI: | 10.1016/j.tetlet.2017.02.037 |
| Popis: | International audience; A library of 864 extracts prepared from Irish marine organisms was screened in the search for novel antioxidants. Chemical investigation of the most promising extract obtained from the common lichen Lichina pygmaea led to the isolation of five resorcinol derivatives. An unusual urea moiety was found embedded in two of these compounds, pygmanilines A (1) and B (2) and their structures were confirmed by one-step chemical syntheses |
| Databáze: | OpenAIRE |
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