Determination of the value of albumin, anti-thrombin III, fibrinogen and D-dimer factors in the diagnosis of asymptomatic pulmonary embolism in patients with nephrotic syndrome
| Autor: | Amin sadat Sharif, Sepideh Hekmat, Nasrin Hoseiny Nejad, Hasan Otukesh, Rozita Hosseini Shamsabadi, Maryam Sakhaei |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Nephrotic Syndrome 030232 urology & nephrology Perfusion scanning 030204 cardiovascular system & hematology Hematocrit Fibrinogen Asymptomatic Gastroenterology Fibrin Fibrinogen Degradation Products 03 medical and health sciences 0302 clinical medicine Internal medicine D-dimer medicine Humans Child Serum Albumin medicine.diagnostic_test business.industry Thrombin Heparin medicine.disease Pulmonary embolism Nephrology Child Preschool Pediatrics Perinatology and Child Health medicine.symptom business Pulmonary Embolism Nephrotic syndrome medicine.drug |
| Zdroj: | Pediatric nephrology (Berlin, Germany). 36(7) |
| ISSN: | 1432-198X |
| Popis: | Thromboembolism is one of the most important and dangerous complications of nephrotic syndrome. This study aimed to determine the value of albumin, anti-thrombin III, fibrinogen and D-dimer factors in the prediction of asymptomatic pulmonary embolism in patients with nephrotic syndrome in non-remission period.Plasma levels of albumin, anti-thrombin III, fibrinogen and D-dimer were assessed in 30 nephrotic children in non-remission period (including new case-patient or relapse period), and the results were compared with chest X-ray and lung perfusion scintigraphy (Q scan).The mean age of patients was 6.22 ± 3.5 years (range 2-12 years). Of patients, 23.3% had abnormal findings in perfusion scan suggestive of pulmonary emboli despite absence of any respiratory manifestations. Median plasma albumin and anti-thrombin III levels in patients with asymptomatic pulmonary embolism were lower than in patients without pulmonary embolism. Also, median fibrinogen and D-dimer levels in patients with asymptomatic pulmonary embolism were higher than in patients without pulmonary embolism, with no statistically significant differences between sex, age, hemoglobin and hematocrit of patients and lung perfusion scan results.Patients with abnormal blood levels of albumin (3.5 g/dl), anti-thrombin III (80 ml/dl), fibrinogen (400 ml/dl) and D-dimer (0.5 μg/dl) underwent CXR/Q scan and were treated with heparin if there was pulmonary embolism. |
| Databáze: | OpenAIRE |
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