A comparative evaluation of the biological effects of environmental cadmium-contaminated control diet and laboratory-cadmium supplemented test diet
| Autor: | Samuel Ogheneovo Asagba, F. O. Obi |
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| Rok vydání: | 2005 |
| Předmět: |
Male
inorganic chemicals chemistry.chemical_element Food Contamination Body weight General Biochemistry Genetics and Molecular Biology Comparative evaluation Biomaterials Toxicology Superoxide dismutase chemistry.chemical_compound Animal science Malondialdehyde Animals Atpase activity Rats Wistar Cadmium biology Superoxide Dismutase Body Weight Metals and Alloys Organ Size Contamination Catalase Rats Liver chemistry Dietary Supplements Toxicity biology.protein Sodium-Potassium-Exchanging ATPase Environmental Pollution General Agricultural and Biological Sciences |
| Zdroj: | BioMetals. 18:155-161 |
| ISSN: | 1572-8773 0966-0844 |
| DOI: | 10.1007/s10534-004-4257-2 |
| Popis: | This study was designed to examine the effects of a diet contaminated by environmental cadmium on organ/body weight ratio and selected toxicological indices. It was also designed to permit a comparative analysis of the effects of the diet contaminated by environmental cadmium and that of cadmium supplemented diet based on the same parameters. Our results show that even though the cadmium content of the environmental cadmium contaminated diet was 300% less than that of the cadmium supplemented diet, the former caused statistically significant changes in Superoxide dismutase (SOD) activity (P < 0.025), Na+/K+ ATPase activity (P < 0.005) and Malondialdehyde (MDA) level (P < 0.025) when values at the end of 1 month exposure were compared to the values at the end of 3 months exposure. These parameters were altered in the same manner by the cadmium content of the supplemented diet in addition to significant reduction in liver/body weight ratio(P < 0.005) within the exposure periods examined. By virtue of the very close nature of the values of these parameters in rats exposed to the two different diets, it appears that the background cadmium (cadmium from the environment) content of the diets is largely responsible for the observed changes, except in the case of liver/body weight ratio. |
| Databáze: | OpenAIRE |
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