Norovirus genotype diversity associated with gastroenteritis outbreaks in aged-care facilities
| Autor: | John A. Marshall, Leesa D. Bruggink, Natalie L. Dunbar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Genotype Victoria Epidemiology Molecular Sequence Data Short Report Sequence Homology Biology medicine.disease_cause Disease Outbreaks medicine Cluster Analysis Homes for the Aged Humans Aged care Phylogeny Aged Caliciviridae Infections Aged 80 and over Incidence (epidemiology) Norovirus Outbreak Sequence Analysis DNA Virology Gastroenteritis Vaccination Infectious Diseases Capsid RNA Viral Capsid Proteins |
| Zdroj: | Epidemiol Infect |
| Popis: | SUMMARYNoroviruses are a major cause of gastroenteritis. Vaccine strategies against norovirus are currently under consideration but depend on a detailed knowledge of the capsid genotypes. This study examined the incidence of norovirus outbreaks in residential aged-care facilities in Victoria, Australia over one year (2013) and documented the (capsid) norovirus genotypes associated with these outbreaks. It was found that 65·0% of 206 outbreaks tested were associated with norovirus infection, thereby showing norovirus to be the major cause of viral gastroenteritis in residential aged-care facilities. Fifteen capsid (open reading frame 2) genotypes were identified as follows: GI.2 (0·9%), GI.3 (1·8%), GI.4 (3·7%), GI.6 (0·9%), GI.7 (0·9%), GI.8 (0·9%), GII.1 (0·9%), GII.2 (0·9%), GII.3 (1·8%), GII.4 (2009-like) (0·9%), GII.4 (2012) (48·6%), GII.4 (2012-like) (16·5%), GII.4 (unknown) (9·2%), GII.5 (2·8%), GII.6 (0·9%), GII.7 (0·9%), GII.13 (6·4%) and an as yet unclassified GII genotype (0·9%). Although GII.4 was the most common norovirus capsid genotype detected, the great diversity of norovirus genotypes in the elderly indicates vaccination strategies for this demographic are not straightforward. |
| Databáze: | OpenAIRE |
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