Appearance of estrogen positive bilateral breast carcinoma with HER2 gene amplification in a patient with aplastic anemia
| Autor: | Vladimir Jurisic, Tatjana Terzic, Milena Todorovic, Milica R. Čolović, Natasa Colovic, Katarina Karadzic |
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| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Receptor ErbB-2 Breast Neoplasms Adenocarcinoma Pathology and Forensic Medicine Breast cancer medicine Carcinoma Humans Aplastic anemia business.industry Bilateral Breast Carcinoma Carcinoma Ductal Breast Gene Amplification Cancer Anemia Aplastic Estrogens General Medicine Middle Aged medicine.disease Squamous carcinoma Female Breast carcinoma business |
| Zdroj: | Polish journal of pathology : official journal of the Polish Society of Pathologists. 65(1) |
| ISSN: | 1233-9687 |
| Popis: | Immunosuppressive therapy is one of the standard therapy protocols for aplastic anemia (AA). However, immunosuppressive therapy and androgenic steroids can promote development of solid tumors such as squamous carcinoma, head and neck tumors, adenocarcinoma of the stomach, hepatocarcinoma and breast carcinoma in long surviving patients with aplastic anemia. We present here a rare case of a 56-year-old woman in whom bilateral adenocarcinoma of the breast developed 11 years after the start of immunosuppressive and androgenic steroid therapy for aplastic anemia. Histological examination showed invasive ductal carcinoma with intense nuclear staining for estrogen receptors. Her2 immunohistochemistry was positive for 80% of stained cells, and chromogenic in situ hybridization showed a high level of HER2 gene amplification. This case indicated that a new therapy option is needed for estimation and evaluation to avoid the consequence of cancer occurrence. |
| Databáze: | OpenAIRE |
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