Altered auditory processing and effective connectivity in 22q11.2 deletion syndrome
| Autor: | Marta I. Garrido, W. Baare, Michael Didriksen, Michelle Rosgaard Birknow, Elvira Fischer, Anders Vangkilde, Oliver J. Hulme, Line Olsen, Henriette Schmock, Morten Mørup, Thomas Werge, Kit Melissa Larsen, Hartwig R. Siebner |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Heterozygote medicine.medical_specialty Adolescent Mismatch negativity Prefrontal Cortex Audiology Auditory cortex behavioral disciplines and activities Temporal lobe Young Adult 03 medical and health sciences Spatio-Temporal Analysis 0302 clinical medicine 22q11 Deletion Syndrome DiGeorge Syndrome Humans Medicine EEG Child Prefrontal cortex Oddball paradigm Biological Psychiatry Auditory Cortex Temporal cortex 22q11 deletion syndrome business.industry Electroencephalography Models Theoretical medicine.disease Temporal Lobe 030227 psychiatry Psychiatry and Mental health Schizophrenia Auditory Perception Evoked Potentials Auditory Female business Dynamic causal modelling 030217 neurology & neurosurgery N1 component |
| Zdroj: | Larsen, K M, Mørup, M, Birknow, M R, Fischer, E, Hulme, O, Vangkilde, A, Schmock, H, Baaré, W F C, Didriksen, M, Olsen, L, Werge, T, Siebner, H R & Garrido, M I 2018, ' Altered auditory processing and effective connectivity in 22q11.2 deletion syndrome ', Schizophrenia Research . https://doi.org/10.1016/j.schres.2018.01.026 |
| DOI: | 10.1016/j.schres.2018.01.026 |
| Popis: | 22q11.2 deletion syndrome (22q11.2DS) is one of the most common copy number variants and confers a markedly increased risk for schizophrenia. As such, 22q11.2DS is a homogeneous genetic liability model which enables studies to delineate functional abnormalities that may precede disease onset. Mismatch negativity (MMN), a brain marker of change detection, is reduced in people with schizophrenia compared to healthy controls. Using dynamic causal modelling (DCM), previous studies showed that top-down effective connectivity linking the frontal and temporal cortex is reduced in schizophrenia relative to healthy controls in MMN tasks. In the search for early risk-markers for schizophrenia we investigated the neural basis of change detection in a group with 22q11.2DS. We recorded high-density EEG from 19 young non-psychotic 22q11.2 deletion carriers, as well as from 27 healthy non-carriers with comparable age distribution and sex ratio, while they listened to a sequence of sounds arranged in a roving oddball paradigm. Despite finding no significant reduction in the MMN responses, whole-scalp spatiotemporal analysis of responses to the tones revealed a greater fronto-temporal N1 component in the 22q11.2 deletion carriers. DCM showed reduced intrinsic connection within right primary auditory cortex as well as in the top-down, connection from the right inferior frontal gyrus to right superior temporal gyrus for 22q11.2 deletion carriers although not surviving correction for multiple comparison. We discuss these findings in terms of reduced adaptation and a general increased sensitivity to tones in 22q11.2DS. |
| Databáze: | OpenAIRE |
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