Decreased blood CD4+PD-1+ and CD8+PD-1+ T cells in psoriatic patients with and without arthritis
| Autor: | Dorota Krasowska, Joanna Purkot, Anna Michalak-Stoma, Ewelina Zakrzewska, Grażyna Chodorowska, Krzysztof Giannopoulos, Joanna Bartosińska, Małgorzata Kowal |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
CD3
Arthritis Dermatology Flow cytometry Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Immune system Psoriasis Immunology and Allergy Medicine 030203 arthritis & rheumatology psoriatic arthritis programmed death 1 Original Paper medicine.diagnostic_test biology business.industry psoriasis medicine.disease Immunology biology.protein business CD8 |
| Zdroj: | Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii |
| ISSN: | 2299-0046 1642-395X |
| Popis: | Introduction Psoriasis with and without arthritis have common immunological mechanisms which among others involve the interactions between cytokines produced by T cells, including Th1, Th17 and Th22. Although quite a lot is known about psoriasis pathogenesis, the cause of chronic immune activation and response in the disease remains unclear. One of the negative regulators of the immune system is programmed death 1 (PD-1). Aim To assess the expression level of PD-1 in the peripheral T cells of psoriatic patients with and without arthritis. Material and methods The study included 23 psoriatic patients with arthritis, 52 psoriatic patients without arthritis and 52 healthy controls. The percentages of CD3+, CD4+, CD8+, CD4+PD-1+ and CD8+PD-1+ T cells were analyzed using flow cytometry. Results The percentages of CD4+PD-1+ as well as CD8+PD-1+ T cells in the psoriatic patients both with and without arthritis were significantly lower than in the control group. The percentages of CD4+PD-1+ as well as CD8+PD-1+T cells were not significantly different between the psoriatic patients with and without arthritis. A significant positive correlation between PD-1 expression on the CD4+ and CD8+ T cells was found in the psoriatic patients without arthritis. Conclusions Impairment of the negative co-stimulation from PD-1 may be another common characteristic of psoriasis both with and without arthritis. |
| Databáze: | OpenAIRE |
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