Relief of hot flushes with new plant-derived 10-component synthetic conjugated estrogens
| Autor: | Brenda M. Williams, Samuel A. Lederman, Rhonda Y. Vega, Wulf H. Utian, Thomas W. Leonard, William D. Koltun |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Erythema medicine.drug_class Administration Oral Placebo Gastroenterology Risk Assessment Severity of Illness Index Drug Administration Schedule law.invention Randomized controlled trial Double-Blind Method Estradiol Congeners law Reference Values Internal medicine Severity of illness medicine Humans Adverse effect Probability Estrogens Conjugated (USP) Vasomotor Dose-Response Relationship Drug business.industry Plant Extracts Estrogen Replacement Therapy Obstetrics and Gynecology Middle Aged Prognosis Clinical trial Endocrinology Treatment Outcome Estrogen Hot Flashes Female medicine.symptom Menopause business |
| Zdroj: | Obstetrics and gynecology. 103(2) |
| ISSN: | 0029-7844 |
| Popis: | OBJECTIVE: A study was conducted to evaluate the safety and efficacy of 3 different doses of synthetic conjugated estrogens B, a new plant-derived 10-component conjugated estrogens product, for the treatment of menopausal vasomotor symptoms. METHODS: This was a randomized, double-blind, placebo-controlled trial. Highly symptomatic menopausal women (N= 281) received 12 weeks of a once-daily oral treatment with 0.3 mg, 0.625 mg, or 1.25 mg of 10-component synthetic conjugated estrogen or placebo. Patients recorded the daily frequency and severity of hot flushes. Statistical analyses compared results at weeks 4, 8, and 12 with baseline values. RESULTS: Statistically significant reductions (P |
| Databáze: | OpenAIRE |
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