Sequential changes in plasma selenium concentration after cadaveric renal transplantation
| Autor: | D A Oleesky, S C Smith, Gareth Morris-Stiff, W.A. Jurewicz |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Adolescent chemistry.chemical_element Gastroenterology Tacrolimus law.invention Nephropathy Selenium Randomized controlled trial law Internal medicine Blood plasma Cadaver Medicine Humans Aged Kidney business.industry Peripheral Nervous System Diseases Middle Aged medicine.disease Kidney Transplantation Surgery Clinical trial Transplantation medicine.anatomical_structure chemistry Cyclosporine Kidney Failure Chronic Female business Immunosuppressive Agents |
| Zdroj: | The British journal of surgery. 91(3) |
| ISSN: | 0007-1323 |
| Popis: | Background Previous investigations have shown that plasma selenium concentrations are significantly lower in patients with established chronic graft nephropathy (CGN) than in healthy transplant controls. The aims of this study were to determine when in the transplant process low selenium concentrations become apparent and to explore the relationship between selenium levels and risk factors for CGN. Methods Plasma selenium concentrations were measured in 40 patients (20 receiving cyclosporin, 20 receiving tacrolimus) undergoing transplantation. Samples were obtained immediately before transplantation and at 3, 6 and 12 months after transplantation. Results A low plasma selenium concentration was found in 30 patients at the time of transplantation but this had normalized in the majority of patients by 3 months. Plasma selenium concentrations at 3, 6 and 12 months were significantly higher than baseline values for both treatment arms, but were significantly lower at 3 months in patients who experienced either clinical acute rejection (CAR) or cytomegalovirus (CMV) infection during the preceding months. Conclusion Low plasma selenium concentrations are common at the time of transplantation but appear to normalize thereafter. The identification of low selenium levels in patients who experience CAR or CMV (two important risk factors for clinically apparent CGN) suggests that the relationship between selenium and CGN warrants further investigation. |
| Databáze: | OpenAIRE |
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