Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse
| Autor: | Mingqiang He, Jihui Jia, Hong Li, Ning Zhang |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Curcumin
Ovalbumin medicine.drug_class Interleukin-1beta Immunology Anti-Inflammatory Agents Mucous membrane of nose Biology Immunoglobulin E Histamine Release Anti-inflammatory Cell Line Proinflammatory cytokine Mice chemistry.chemical_compound NF-KappaB Inhibitor alpha medicine Animals Humans Mast Cells Mice Inbred BALB C Interleukin-6 Tumor Necrosis Factor-alpha Myocardium Interleukin-8 Mast cell Rhinitis Allergic Mice Inbred C57BL Nasal Mucosa Oxidative Stress medicine.anatomical_structure chemistry biology.protein Female I-kappa B Proteins Mitogen-Activated Protein Kinases Histamine |
| Zdroj: | Cellular Immunology. 298:88-95 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/j.cellimm.2015.09.010 |
| Popis: | Curcumin has commonly been used for the treatment of various allergic diseases. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In the present study, the effect of curcumin on allergic responses in ovalbumin (OVA)-induced allergic rhinitis mouse was investigated. We explored the effect of curcumin on the release of allergic inflammatory mediators, such as histamine, OVA-specific IgE, and inflammatory cytokines. Also, we found that curcumin improved rhinitis symptoms, inhibited the histopathological changes of nasal mucosa, and decreased the serum levels of histamine, OVA-specific IgE and TNF-α in OVA-induced allergic rhinitis mice. In addition, curcumin suppressed the production of inflammatory cytokines, such as TNF-α, IL-1β, IL-6 and IL-8. Moreover, curcumin significantly inhibited PMA-induced p-ERK, p-p38, p-JNK, p-Iκ-Bα and NF-κB. These findings suggest that curcumin has an anti-allergic effect through modulating mast cell-mediated allergic responses in allergic rhinitis, at least partly by inhibiting MAPK/NF-κB pathway. |
| Databáze: | OpenAIRE |
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