Clock-Talk: Interactions between Central and Peripheral Circadian Oscillators in Mammals
| Autor: | Schibler, Ueli, Gotic, Ivana, Saini, Camille, Gos, Pascal, Curie, Thomas, Emmenegger, Yann, Sinturel, Flore, Gosselin, Pauline, Gerber, Alan, Fleury-Olela, Fabienne, Rando, Gianpaolo, Demarque, Maud, Franken, Paul, Grodzicker, Terri, Stillman, Bruce, Stewart, David |
|---|---|
| Přispěvatelé: | Organic Chemistry, AIMMS, Grodzicker, Terri, Stillman, Bruce, Stewart, David |
| Rok vydání: | 2016 |
| Předmět: |
endocrine system
Circadian clock Biology Biochemistry Retina Body Temperature Mice 03 medical and health sciences Receptors Glucocorticoid 0302 clinical medicine Biological Clocks Circadian Clocks Genetics Zeitgeber Animals Humans Circadian rhythm Glucocorticoids Molecular Biology 030304 developmental biology Mammals 0303 health sciences Suprachiasmatic nucleus Ecology Fasting Feeding Behavior Actins Circadian Rhythm Rats Light effects on circadian rhythm nervous system Hypothalamus Suprachiasmatic Nucleus sense organs Cues Entrainment (chronobiology) Neuroscience 030217 neurology & neurosurgery Retinohypothalamic tract hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | Cold Spring Harbor Symposia on Quantitative Biology Cold Spring Harb Symp Quant Biol 21st Century Genetics Genes at Work, 2015, 223-232 STARTPAGE=223;ENDPAGE=232;TITLE=21st Century Genetics Genes at Work, 2015 Schibler, U, Gotic, I, Saini, C, Gos, P, Curie, T, Emmenegger, Y, Sinturel, F, Gosselin, P, Gerber, A, Fleury-Olela, F, Rando, G, Demarque, M & Franken, P 2016, Clock-Talk : Interactions between central and peripheral circadian oscillators in mammals . in T Grodzicker, B Stillman & D Stewart (eds), 21st Century Genetics Genes at Work, 2015 . Cold Spring Harbor Symposia on Quantitative Biology, vol. 80, Cold Spring Harbor Laboratory Press, pp. 223-232, 21st Century Genetics Genes at Work, 2015, Huntington, United States, 26/05/15 . https://doi.org/10.1101/sqb.2015.80.027490 |
| DOI: | 10.1101/sqb.2015.80.027490 |
| Popis: | In mammals, including humans, nearly all physiological processes are subject to daily oscillations that are governed by a circadian timing system with a complex hierarchical structure. The central pacemaker, residing in the suprachiasmatic nucleus (SCN) of the ventral hypothalamus, is synchronized daily by photic cues transmitted from the retina to SCN neurons via the retinohypothalamic tract. In turn, the SCN must establish phase coherence between self-sustained and cell-autonomous oscillators present in most peripheral cell types. The synchronization signals (Zeitgebers) can be controlled more or less directly by the SCN. In mice and rats, feeding-fasting rhythms, which are driven by the SCN through rest-activity cycles, are the most potent Zeitgebers for the circadian oscillators of peripheral organs. Signaling through the glucocorticoid receptor and the serum response factor also participate in the phase entrainment of peripheral clocks, and these two pathways are controlled by the SCN independently of feeding-fasting rhythms. Body temperature rhythms, governed by the SCN directly and indirectly through rest-activity cycles, are perhaps the most surprising cues for peripheral oscillators. Although the molecular makeup of circadian oscillators is nearly identical in all cells, these oscillators are used for different purposes in the SCN and in peripheral organs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|