Identification of the protective effect of Polygonatum sibiricum polysaccharide on d-galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network

Autor: Wenqun Li, Weijun Peng, Min Yi, Bo Yang, Jianhua Huang, Zheyu Zhang, Pengji Yi
Rok vydání: 2021
Předmět:
Male
Aging
Polygonatum sibiricum
anti-ageing
Pharmaceutical Science
Natural bioactive substances
Polysaccharide
030226 pharmacology & pharmacy
01 natural sciences
Mice
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
synapse
Polysaccharides
Circular RNA
Drug Discovery
Animals
circRNA
RNA
Messenger
Maze Learning
Pharmacology
chemistry.chemical_classification
Behavior
Animal
Dose-Response Relationship
Drug
biology
ceRNA theory
Competing endogenous RNA
Liliaceae
Gene Expression Profiling
Polygonatum
Brain
Galactose
RNA sequencing
RNA
Circular
General Medicine
Anti ageing
biology.organism_classification
eye diseases
0104 chemical sciences
MicroRNAs
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
chemistry
Biochemistry
Ageing
Molecular Medicine
Research Article
Zdroj: Pharmaceutical Biology
article-version (VoR) Version of Record
ISSN: 1744-5116
1388-0209
DOI: 10.1080/13880209.2021.1893347
Popis: Context Polygonatum sibiricum polysaccharide (PSP), derived from Polygonatum sibiricum Delar. ex Redoute (Liliaceae), is known to be able to delay the ageing process. However, the specific mechanisms underlying these effects are not clear. Objective To investigate the mechanisms underlying the effects of PSP treatment on brain ageing by the application of transcriptomic analysis. Materials and methods Forty Kunming mice were randomly divided into four groups (control, d-galactose, low-dose PSP, high-dose PSP). Mice were administered d-galactose (50 mg/kg, hypodermic injection) and PSP (200 or 400 mg/kg, intragastric administration) daily for 60 days. Behavioural responses were evaluated with the Morris water maze and the profiles of circRNA, miRNA, and mRNA, in the brains of experimental mice were investigated during the ageing process with and without PSP treatment. Results PSP improved cognitive function during brain ageing, as evidenced by a reduced escape latency time (p
Databáze: OpenAIRE
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