Modifying effects of components of plant essence on the induction of sister-chromatid exchanges in cultured Chinese hamster ovary cells
| Autor: | Hisako Imanishi, Toshihiro Ohta, Yasuhiko Shirasu, YüF. Sasaki |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Coumaric Acids
Ultraviolet Rays Mitomycin Jasmone Hamster Sister chromatid exchange Biology In Vitro Techniques Chinese hamster Cell Line Mitomycins Ferulic acid chemistry.chemical_compound Structure-Activity Relationship Caffeic Acids Cricetulus Scopoletin Cricetinae Caffeic acid Animals Plant Extracts Chinese hamster ovary cell X-Rays Cell Cycle food and beverages Drug Synergism General Medicine biology.organism_classification chemistry Biochemistry Sister Chromatid Exchange |
| Zdroj: | Mutation research. 226(2) |
| ISSN: | 0027-5107 |
| Popis: | The influcence of 21 kinds of components of plant essence on sister-chromatid exchanges (SCEs) induced by mitomycin C was investigated in cultured Chinese hamster CHO K-1 cells. Posttreatment with scopoletin, jasmone, caffeic acid and ferulic acid significantly increased the frequency of SCEs. Further investigation of the SCE-enhancing effect of analogues of caffeic acid and ferulic acid revealed that an α,β-unsaturated carbonyl group may be necessary for SCE-enhancing effects. The influence of caffeic acid and ferulic acid on X-ray- or UV-induced SCEs was also studied. The frequencies of SCEs induced by UV were increased by treatment with these compounds. This increasing effect was observed in the S phase of the cell cycle. On the contrary, X-ray-induced SCEs were reduced by the treatment with these compounds. The decreasing effect was observed in the G1 phase but not in the S or G2 phase. To explain these contradictory results, we assumed that caffeic acid and ferulic acid may modify the repair of DNA strand breaks. |
| Databáze: | OpenAIRE |
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