The Dopamine Receptor D5 May Influence Age of Onset
| Autor: | Kanyakumarika Sarkar, Subhamita Maitra, Kanchan Mukhopadhyay, Swagata Sinha |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Proband medicine.medical_specialty Endophenotypes India Late onset Polymorphism Single Nucleotide Severity of Illness Index White People 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype Dopamine receptor D5 medicine Humans Genetic Predisposition to Disease Receptors Dopamine D5 Age of Onset Child Psychiatry Haplotype Exons Disease etiology 030104 developmental biology Endocrinology Haplotypes Attention Deficit Disorder with Hyperactivity Dopamine receptor Case-Control Studies Pediatrics Perinatology and Child Health Female Neurology (clinical) Age of onset Psychology 030217 neurology & neurosurgery |
| Zdroj: | Journal of Child Neurology. 31:1250-1256 |
| ISSN: | 1708-8283 0883-0738 |
| Popis: | The objective was to investigate contribution of the dopamine receptor 5 (DRD5) gene variants in the symptoms of attention-deficit/hyperactivity disorder (ADHD) probands since brain regions identified to be affected in these group of patients have higher expression of the DRD5 receptor. Out of 22 exonic variants, 19 were monomorphic in the Indo-Caucasoid individuals. rs6283 “C” and rs113828117 “A” exhibited significant higher occurrence in families with ADHD probands. Several haplotypes showed biased occurrence in the probands. Early and late onset groups exhibited significantly different genotypic frequencies. A new G>A substitution was observed in the control samples only. The late onset group exhibited higher scores for hyperactivity as compared to the early onset group. The authors infer that the age of onset of ADHD may at least partially be affected by DRD5 variants warranting further investigation on the role of DRD5 in the disease etiology. |
| Databáze: | OpenAIRE |
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