Mucoadhesive Nanoparticles for Drug Delivery to the Anterior Eye
| Autor: | Megan Dodd, Nicole Mangiacotte, Graeme Prosperi-Porta, Heather Sheardown, Lina Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
General Chemical Engineering
Nanoparticle dexamethasone 02 engineering and technology 010402 general chemistry Methacrylate 01 natural sciences Article lcsh:Chemistry chemistry.chemical_compound Cystamine Mucoadhesion General Materials Science Phenylboronic acid drug release chemistry.chemical_classification HEMA Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences 3. Good health Contact lens chemistry lcsh:QD1-999 Drug delivery eyedrops Nanoparticles 0210 nano-technology Nuclear chemistry |
| Zdroj: | Nanomaterials, Vol 10, Iss 1400, p 1400 (2020) Nanomaterials Volume 10 Issue 7 |
| ISSN: | 2079-4991 |
| Popis: | While the use of topical drops for the delivery of drugs to the anterior of the eye is well accepted, it is far from efficient with as little as 5% of the drug instilled on the eye actually reaching the target tissue. The ability to prolong the residence time on the eye is desirable. Based on the acceptability of 2-hydroxyethyl methacrylate based polymers in contact lens applications, the current work focuses on the development of a poly(2-hydroxyethyl methacrylate (HEMA)) nanoparticle system. The particles were modified to allow for degradation and to permit mucoadhesion. Size and morphological analysis of the final polymer products showed that nano-sized, spherical particles were produced. FTIR spectra demonstrated that the nanoparticles comprised poly(HEMA) and that 3-(acrylamido)phenylboronic acid (3AAPBA), as a mucoadhesive, was successfully incorporated. Degradation of nanoparticles containing N,N&prime bis(acryloyl)cystamine (BAC) after incubation with DL-dithiothreitol (DTT) was confirmed by a decrease in turbidity and through transmission electron microscopy (TEM). Nanoparticle mucoadhesion was shown through an in-vitro zeta potential analysis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|