Effect of hydrogen sulfide-releasing aspirin on esophageal and gastric mucosa compromised by stress injury
| Autor: | E. M. Gavriluk, O. I. Grushka, I. O. Pshyk-Titko, O. S. Zayachkivska, N. S. Bula, J. L. Wallace, Ya. I. Pavlovskiy |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Aspirin business.industry Hydrogen sulfide Biochemistry Stress injury Gastroenterology 3. Good health lcsh:Biochemistry 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Internal medicine medicine Gastric mucosa lcsh:QD415-436 business medicine.drug |
| Zdroj: | Ukrainian Biochemical Journal, Vol 89, Iss SI01, Pp 93-101 (2017) |
| ISSN: | 2409-4943 |
| DOI: | 10.15407/ubj89.si01.093 |
| Popis: | Recent data of study H2S in gastrointestinal tract has proven its potent cytoprotection on mucosal defense among acid-related diseases in the gut. The aim was to evaluate the effects of H2S-releasing aspirin derivative (ATB-340) on esophageal and gastric mucosa compromised by stress injury. Rats were treated with vehicle (control), aspirin (10 mg/kg), ATB-340 (17.5 mg/kg) single or 9 days duration, with or without induction of stress injury. Esophageal mucosa, gastric mucosa were estimated by histopathological damage scoring. Serological levels of VCAM-1, IL-6 by ELISA. ATB-340 treatment resulted in protective effect and lower grade of damage score in esophageal mucosa and gastric mucosa lesions vs effect of aspirin in single or 9 days applications. The serum levels of VCAM, IL-6 in rats who were aspirin-treated and subjected to stress-injury were higher than those in control animals. Treatment with ATB-340 produced an anti-inflammatory effect by decreasing VCAM and IL-6 vs aspirin. Cytoprotective effect of ATB-340 on esophageal mucosa and gastric mucosa was modulated by inhibiting inflammation and improving endothelial functions |
| Databáze: | OpenAIRE |
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