Mitochondrial Haplogroups Are Associated With Severity of Diabetic Retinopathy
| Autor: | Christopher B. Estopinal, Milam A. Brantley, Rachel M. Roberson, Isaac M. Chocron, Megan B. Parks, L. Goodwin Burgess, Emily A. Wade, David C. Samuels |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Mitochondrial DNA Genotype endocrine system diseases Haplogroup Cohort Studies Internal medicine Diabetes mellitus Odds Ratio medicine Humans Aged Glycated Hemoglobin Diabetic Retinopathy business.industry Haplotype Case-control study Articles Diabetic retinopathy Odds ratio Middle Aged medicine.disease humanities eye diseases Mitochondria Diabetes Mellitus Type 1 Endocrinology Diabetes Mellitus Type 2 Haplotypes Case-Control Studies Female sense organs business Human mitochondrial DNA haplogroup |
| Zdroj: | Investigative Opthalmology & Visual Science. 55:5589 |
| ISSN: | 1552-5783 |
| DOI: | 10.1167/iovs.14-15149 |
| Popis: | To determine if specific mitochondrial haplogroups associate with nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR).Deidentified medical records for Caucasian patients with diabetic retinopathy (DR; 153 NPDR and 138 PDR) were obtained from BioVU, Vanderbilt University's electronic, deidentified DNA databank. An independent cohort of Caucasian patients with DR (44 NPDR and 57 PDR) from the Vanderbilt Eye Institute (VEI) was used for validation. We tested for an association between mitochondrial haplogroups and PDR among patients with DR.In the BioVU cohort, PDR frequency among Caucasian DR patients differed significantly by mitochondrial haplogroup (P = 0.027). Replication in the VEI cohort confirmed this association (P = 0.0064). In the combined cohort, patients from the common haplogroup H were more likely to have PDR (odds ratio [OR] = 2.0 [95% confidence interval (CI) = 1.3-3.0], P = 0.0012), while patients from haplogroup Uk were less likely to have PDR (OR = 0.5 [95% CI = 0.3-0.8], P = 0.0049). In logistic regression analyses, the addition of diabetes duration, hemoglobin A1c (HgbA1c) levels, and hypertension had no effect on the associations of haplogroups H and Uk with PDR.In this study, DR patients from mitochondrial haplogroup H were more likely to have PDR, while DR patients from haplogroup Uk were less likely to have PDR. The association was independent of the major clinical variables affecting PDR. The mitochondrial haplogroups were as strong a risk factor for PDR as were elevated HgbA1c levels. |
| Databáze: | OpenAIRE |
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