| Autor: |
Derek Simonsen, Jacob Heffelfinger, David M. Cwiertny, Hans-Joachim Lehmler |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Environmental Toxicology and Pharmacology. 96:104008 |
| ISSN: |
1382-6689 |
| DOI: |
10.1016/j.etap.2022.104008 |
| Popis: |
The metabolism and toxicity of current-use herbicide safeners remain understudied. We investigated the enantioselective metabolism of the safener benoxacor in Rhesus monkey subcellular fractions. Benoxacor was incubated with liver microsomes and cytosol from female and male monkeys (≤30 min). Benoxacor levels and enantiomeric fractions were determined with gas chromatography. Benoxacor was metabolized by microsomal cytochrome P450 enzymes (CYPs), cytosolic glutathione-S-transferases (GSTs), and microsomal and cytosolic carboxylesterase (CESs). CES-mediated microsomal metabolism followed the order males females, whereas the CYP-mediated clearance followed the order females males. CYP-mediated metabolism initially resulted in an enrichment of the second eluting benoxacor enantiomer (E |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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