Insulin modifies flavor aversions and preferences in real- and sham-feeding rats
| Autor: | D. A. Vanderweele, R. O. Deems, R. B. Kanarek |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Blood Glucose
Male Taste medicine.medical_specialty Liquid diet Physiology medicine.medical_treatment Drinking Hypoglycemia Food Preferences Physiology (medical) Internal medicine Medicine Animals Insulin Saline Pancreatic hormone Gastric emptying Dose-Response Relationship Drug business.industry Osmolar Concentration food and beverages Rats Inbred Strains Fasting medicine.disease Sham feeding Rats Endocrinology Milk business |
| Zdroj: | The American journal of physiology. 259(4 Pt 2) |
| ISSN: | 0002-9513 |
| Popis: | In separate, parallel experiments, rats were allowed to sham or real feed a flavored sweetened condensed-milk solution after a 17.5-h fast. Coinciding with administration of the milk were injections of insulin or vehicle (saline). Insulin had no effect on intake in the real feeding situation, and flavors paired with insulin (0.8, 2.5, or 5.0 U/rat) were avoided, relative to saline-paired flavors. In sham-feeding rats, insulin (0.8 U/rat) significantly reduced the amount of milk consumed, and flavors paired with insulin injection were preferred, relative to saline-paired ones. Insulin produced a relatively larger hypoglycemia during sham feeding than during real feeding. Thus it appears that insulin-paired flavors of milk may be preferred by animals when they are ingested in sham feeding but not in animals real feeding. Perhaps rapid gastric emptying, as would occur with a liquid diet, accompanied by increased insulin levels, leads to malaise and flavor aversion. |
| Databáze: | OpenAIRE |
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